Ternary micellar complex composed of a sialoglycosphingolipid, a therapeutically active substance and an antibody
AssigneesConsejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet), Centro de Excelencia en Productos y Procesos (CEPRECOR)
InventorsDante Miguel BELTRAMO, Ariel Gustavo GARRO, Roxana Valeria ALASINO, Victoria LEONHARD
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Abstract
The invention relates to a pharmaceutical composition soluble in an aqueous solution, which is characterised in that it comprises sialoglycosphingolipids; polypeptides selected from the group comprising antibodies, fragments and variants of same; and at least one therapeutically active substance, forming a ternary micellar complex of sialoglycosphingolipid-therapeutically active substance-polypeptide in which the polypeptides are non-covalently associated with the micelles formed by the sialoglycosphingolipid and the therapeutically active substance.
Claims28
A pharmaceutical compound soluble in aqueous solution comprising:
- at least a sialoglycosphingolipid;
- at least one polypeptide selected from the group consisting of antibodies, fragments and variants thereof;
- and at least one therapeutically active substance;
- wherein a ternary micellar complex if formed;
- and wherein said polypeptides are associated in a non-covalent manner with the micelles formed by said sialoglycosphingolipids and said therapeutically active substance.
A pharmaceutical composition, soluble in aqueous solution comprising at least a sialoglycosphingolipid and a therapeutically active substance, which form micelles with the ability to non-covalently bind antibodies on their surfaces, to form a ternary micellar complex, Sialoglycosphingolipid-Therapeutically active substance-Antibody.
Dependencies are inferred from the claim text.