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US 2022/0054639 A1Published application
In-situ stable injectable collagen-based hydrogels for cell and growth factor delivery
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsYunzhi Yang, Seyedsina Moeinzadeh
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Abstract
A stable injectable collagen-based hydrogel delivery platform and method is provided to obtain the viscosity, post-injection stability and mechanical properties needed of an injectable collagen matrix via incorporating alginate and calcium sulfate (CaSO4) into the matrix. The hydrogel (Alg/Col hydrogel) is shear-thinning, injectable through commercially available needles and stable right after injection.
Claims14
A delivery platform for cells or therapeutics, comprising:
- (a) An alginate precursor solution, wherein alginate is dissolved in a calcium free and basic pH medium;
- and
- (b) A collagen and CaSO4 precursor solution, wherein collagen is dissolved in a calcium free and acidic medium supplemented with CaSO4 to make a collagen precursor solution.
A method of delivering cells or therapeutics, comprising:
- (a) having an alginate precursor solution, wherein alginate is dissolved in a calcium free and basic pH medium;
- and
- (b) having a collagen and CaSO4 precursor solution, wherein collagen is dissolved in a calcium free and acidic medium supplemented with CaSO4 to make a collagen precursor solution.
Dependencies are inferred from the claim text.