Norovirus vaccine formulations and methods
AssigneeTakeda Vaccines, Inc.
InventorsTaisei MASUDA, James SHERWOOD, Paul MENDELMAN, Frank BAEHNER
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Abstract
The invention is in the field of vaccines, particularly vaccines for Noroviruses. In addition, the invention relates to methods of preparing vaccine compositions and methods of inducing and evaluating protective immune responses against Norovirus in humans, in particular, pediatric patients.
Claims58
A method for inducing protective immunity against Norovirus infection in a pediatric subject, comprising administering to the subject a composition comprising Norovirus virus-like particles (VLPs) in a dosing regimen, wherein the dosing regimen comprises administering the composition in at least a first dose and a second dose.
The method of any one of claims 1-7, wherein the pediatric subject is between about 6 weeks and about 9 years of age.
A composition comprising genogroup I Norovirus VLPs and genogroup II Norovirus VLPs for use in a method of eliciting protective immunity against norovirus in a pediatric subject.
Use of a composition comprising genogroup I Norovirus VLPs and genogroup II Norovirus VLPs in a method for eliciting protective immunity against Norovirus infection in a pediatric subject.
A method for inducing protective immunity against Norovirus infection in a pediatric subject, comprising the steps of determining the subject's age;
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- (ii) (a) if the age is at least about 6 weeks but less than 6 months, administering to the subject a composition comprising Norovirus virus-like particles (VLPs) in a dosing regimen consisting of administering the composition in three separate doses, and
- (b) if the age is at least 6 months but less than 9 years, administering to the subject a composition comprising Norovirus virus-like particles (VLPs) in a dosing regimen consisting of administering the composition in two separate doses.
Dependencies are inferred from the claim text.