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US 2022/0054620 A1Published application
Vaccines against powassan virus, and methods of using same
AssigneeThe Wistar Institute of Anatomy and Biology
InventorsKar Muthumani, David Weiner, Hyeree Choi, Sagar B. Kudchodkar
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Abstract
An aspect of the present invention is related to nucleic acid constructs capable of expressing at least one Powassan virus (POWV) antigen that elicits an immune response in a mammal against POWV virus, and methods of use thereof.
Claims27
An immunogenic composition comprising a nucleic acid molecule encoding at least one consensus Powassan virus (POWV) antigen.
A nucleic acid molecule encoding a peptide comprising an amino acid sequence selected from the group consisting of
- a) an amino acid sequence having at least about 90% identity over an entire length of the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:6 and SEQ ID NO:10,
- b) an immunogenic fragment comprising at least about 90% identity over at least 60% of the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:6 and SEQ ID NO:10,
- c) the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:6 and SEQ ID NO:10, and
- d) an immunogenic fragment comprising at least 60% of the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:6 and SEQ ID NO:10.
1 more element
A peptide comprising an amino acid sequence selected from the group consisting of
- a) an amino acid sequence having at least about 90% identity over an entire length of the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10 and SEQ ID NO:12,
- b) an immunogenic fragment comprising at least about 90% identity over at least 60% of the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10 and SEQ ID NO:12,
- c) the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10 and SEQ ID NO:12, and
- d) an immunogenic fragment comprising at least 60% of the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10 and SEQ ID NO:12.
1 more element
Dependencies are inferred from the claim text.