Attenuated Bordetella Bronchiseptica Strains, Oral Vaccines Containing the Attenuated Strains, and Methods of Making & Use Thereof
AssigneeBoehringer Ingelheim Animal Health USA Inc.
InventorsLaurent Bernard FISCHER, Edmond JOLIVET, Kevin MILLSAP
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Abstract
The present invention provides attenuated, aroA mutant B. bronchiseptica strains that are effective to elicit an immune response in an animal against B. bronchiseptica. Also provided are immunogenic compositions and vaccines which include the attenuated, aroA mutant B. bronchiseptica strains. Also provided are kits for use with such compositions and vaccines. Also provided are methods of orally administering attenuated, aroA mutant B. bronchiseptica strains, compositions, and vaccines to animals.
Claims20
An attenuated aroA mutant B. bronchiseptica strain capable of eliciting protective immunity against B. bronchiseptica infection in an animal when administered orally to the animal.
An immunogenic composition comprising an attenuated aroA mutant B. bronchiseptica strain capable of eliciting an immune response when administered orally to an animal.
A method for eliciting a protective immune response against B. bronchiseptica in an animal, comprising:
- administering to the animal an oral vaccine comprising an effective amount of an aroA mutant Bordetella bronchiseptica bacteria strain.
Dependencies are inferred from the claim text.