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US 2022/0054614 A1Published application
Inhibition of asph expressing tumor growth and progression
AssigneeRhode Island Hospital
InventorsJack R. Wands, Xiaoqun Dong
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AssigneeRhode Island Hospital
InventorsJack R. Wands, Xiaoqun Dong
Estimating the term…
Disclosed are compositions and methods for an immunotherapy in a subject containing a vaccine construct for an immunization against a purified tumor antigen and a checkpoint inhibitor for treating a tumor in the subject, in which the tumor is characterized as comprising a low frequency of neoantigen expression and the composition potentiates an anti-tumor immune response without inducing autoimmunity in the subject. A pharmaceutical composition containing the composition as an active component and a pharmaceutically acceptable carrier, and a combinatorial composition containing a vaccine construct for an immunization against a purified tumor antigen and an immune checkpoint inhibitor, in which the tumor is characterized as comprising a low frequency of neoantigen expression, are also described.
A composition for immunotherapy for treating a tumor in a subject comprising:
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An immunotherapeutic method of treating a tumor or inhibiting tumor metastasis in a subject, comprising:
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A combinatorial composition comprising a vaccine construct for an immunization against a purified tumor antigen, said tumor being characterized as comprising a low frequency of neoantigen expression, and a checkpoint inhibitor.
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An immunotherapeutic method for inhibiting metastasis in a subject, comprising:
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Dependencies are inferred from the claim text.