Pathogen-associated molecular pattern molecules and rna immunogenic compositions and methods of using the compositions for treating cancer
AssigneeImmune Design Corp.
InventorsPeter Lars Aksel Berglund, Tinglan Tina Albershardt, Jan Henrik Ter Meulen, Jardin Alexandra Leleux
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Abstract
The present invention provides novel compositions and methods for inhibiting tumor growth, treating cancer, and/or inducing immune responses. Such compositions and methods induce an immune response for the treatment of a variety of diseases including cancer.
Claims35
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A method for inducing an immune response in a subject, the method comprising (a) administering to the subject at least one dose of a first composition comprising a PAMP molecule;
- and (b) administering to the subject at least one dose of a second composition comprising a first RNA encoding at least one immunostimulatory molecule, thereby inducing an immune response.
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A kit comprising (a) a first composition comprising PAMP molecule;
- and (b) a second composition comprising a first RNA encoding at least one immunostimulatory molecule.
A product comprising (a) a first composition comprising a PAMP molecule;
- and (b) a second composition comprising a first RNA encoding at least one immunostimulatory molecule, for use in a method selected from the group consisting of (i) inhibiting tumor growth in a subject, (ii) treating cancer in a subject, and (iii) inducing an immune response in a subject.
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Dependencies are inferred from the claim text.