Compositions Comprising Antimicrobial Peptides
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsKenneth Urish, Jonathan Brendan Mandell
Life of this patent
Estimating the term…
Abstract
A method of treating or preventing a microbial infection in a patient is provided, along with a wound irrigation system and a composition in the form of an irrigation liquid for reducing microbial load or preventing microbial infection in a wound.
Claims30
A pharmaceutical composition comprising:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is chosen from the group consisting of:
- SA-5 (SEQ ID NO:
- 1);
- LSA-5 (SEQ ID NO:
- 2);
- WLSA-5 (SEQ ID NO:
- 3);
- LBU-1 (SEQ ID NO:
- 4);
- LBU-2 (SEQ ID NO:
- 5);
- LBU-3 (SEQ ID NO:
- 6);
- LBU-3.5 (SEQ ID NO:
- 7);
- LBU-4 (SEQ ID NO:
- 8);
- WLBU-1 (SEQ ID NO:
- 9);
- WLBU-2 (SEQ ID NO:
- 10);
- WLBU-3 (SEQ ID NO:
- 11);
- WLBU-4 (SEQ ID NO:
- 12);
- WR6 (SEQ ID NO:
- 13);
- WR12 (SEQ ID NO:
- 14);
- WR18 (SEQ ID NO:
- 15), WR 24 (SEQ ID NO:
- 16), or any combination thereof;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid;
- and
- wherein the pharmaceutical composition comprises a total osmolarity of from about 1 mOsm/L to about 350 mOsm/L.
A method of treating or preventing an infection in a subject in need thereof, comprising administering a therapeutically effective amount of a pharmaceutical composition to the subject, thereby treating or preventing the infection;
- wherein the pharmaceutical composition comprises:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is chosen from the group consisting of:
- SA-5 (SEQ ID NO:
- 1);
- LSA-5 (SEQ ID NO:
- 2);
- WLSA-5 (SEQ ID NO:
- 3);
- LBU-1 (SEQ ID NO:
- 4);
- LBU-2 (SEQ ID NO:
- 5);
- LBU-3 (SEQ ID NO:
- 6);
- LBU-3.5 (SEQ ID NO:
- 7);
- LBU-4 (SEQ ID NO:
- 8);
- WLBU-1 (SEQ ID NO:
- 9);
- WLBU-2 (SEQ ID NO:
- 10);
- WLBU-3 (SEQ ID NO:
- 11);
- WLBU-4 (SEQ ID NO:
- 12);
- WR6 (SEQ ID NO:
- 13);
- WR12 (SEQ ID NO:
- 14);
- WR18 (SEQ ID NO:
- 15), WR 24 (SEQ ID NO:
- 16), or any combination thereof;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid;
- and
- wherein the pharmaceutical composition comprises a total osmolarity of from about 1 mOsm/L to about 350 mOsm/L.
A lavage system, comprising an irrigation actuator configured for washing or irrigating a wound in a patient with a pharmaceutical composition, fluidly-connected to a reservoir, wherein the pharmaceutical composition comprises:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is chosen from the group consisting of:
- SA-5 (SEQ ID NO:
- 1);
- LSA-5 (SEQ ID NO:
- 2);
- WLSA-5 (SEQ ID NO:
- 3);
- LBU-1 (SEQ ID NO:
- 4);
- LBU-2 (SEQ ID NO:
- 5);
- LBU-3 (SEQ ID NO:
- 6);
- LBU-3.5 (SEQ ID NO:
- 7);
- LBU-4 (SEQ ID NO:
- 8);
- WLBU-1 (SEQ ID NO:
- 9);
- WLBU-2 (SEQ ID NO:
- 10);
- WLBU-3 (SEQ ID NO:
- 11);
- WLBU-4 (SEQ ID NO:
- 12);
- WR6 (SEQ ID NO:
- 13);
- WR12 (SEQ ID NO:
- 14);
- WR18 (SEQ ID NO:
- 15), WR 24 (SEQ ID NO:
- 16), or any combination thereof;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid;
- and
- wherein the pharmaceutical composition comprises a total osmolarity of from about 1 mOsm/L to about 350 mOsm/L.
Dependencies are inferred from the claim text.