Use of sap for the treatment of eurotiomycetes fungi infections
AssigneesHumanitas Mirasole S.P.A., Humanitas University
InventorsAndrea DONI, Alberto MANTOVANI
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Abstract
Disclosed is the use of Serum Amyloid P component (SAP) polypeptides for the treatment of Eurotiomycetes fungi infections, in particular for aspergillosis and invasive aspergillosis, alone or in combination with pentraxin-3 (PTX3) polypeptides.
Claims20
A method for treatment of an Eurotiomycetes fungus infection, comprising administering a therapeutically effective amount of a Serum Amyloid P component (SAP) polypeptide or functional fragment of such SAP polypeptide, wherein the SAP polypeptide comprises an amino acid sequence that is at least 70% identical to SEQ ID NO:1.
A method for treatment of a Eurotiomycetes fungus infection, comprising administering a therapeutically effective amount of a combination of a SAP polypeptide or a functional fragment of such SAP polypeptide with a Pentraxin 3 (PTX3) polypeptide or a functional fragment of such PTX3 polypeptide, wherein the SAP polypeptide and the PTX3 polypeptide comprise an amino acid sequence that is at least 70% identical to SEQ ID NO:1 and SEQ ID NO:2, respectively.
Dependencies are inferred from the claim text.