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US 2022/0054584 A1Published application
Antimicrobial fusion peptides
AssigneeLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
InventorMichael R. Yeaman
Life of this patent
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Abstract
Antimicrobial peptides, compositions and methods are described that are useful for treating infectious disease, including those caused by drug resistant Gram-negative bacteria (e.g., Pseudomonas and Acinetobacter) and parasite-caused disease such as malaria. The peptides include a modular kinocidin gamma-core connected directly, or through a short spacer, to a kinocidin C-terminal alpha-helix.
Claims17
An isolated peptide comprising:
- (1) a first fragment consisting of the amino acid sequence of SEQ ID NO:2 (CPTAQLIATLKNGRKICLDLQ) or a first amino acid sequence having at least 85% sequence identity to SEQ ID NO:
- 2;
- and
- (2) a second fragment consisting of the amino acid sequence of SEQ ID NO:3 (ALYKKFKKKLLKSLKRLG) or a second amino acid sequence having at least 85% sequence identity to SEQ ID NO:
- 3,
- wherein the first fragment and the second fragment are connected directly or connected through a spacer that is 10 amino acids or fewer in length, and
- wherein the first fragment is at the N-terminal end of the second fragment.
4 more elements
Dependencies are inferred from the claim text.