Method for manufacturing a solid formulation for oral administration, associated facility and solid forumulation

A method for manufacturing a solid formulation for oral administration, said solid formulation comprising an edible substrate portion on which a first composition comprising a first pharmaceutical active ingredient is deposited, said method comprising:

• providing an edible substrate in film form, wherein the film comprises a plurality of portions, each designed to support a quantity Q of the first pharmaceutical active ingredient corresponding to predetermined value Qref;
• spraying onto a portion of the edible substrate a first liquid formulation comprising a first pharmaceutical active ingredient and a first solvent;
• evaporating the first solvent so as to form a first solid composition deposited on the portion of the edible substrate;
• measuring a quantity Q of the first pharmaceutical active ingredient supported by the portion of the edible substrate without destroying the solid composition, and comparing the measured quantity Q to a predetermined value Qref, and
• dividing the edible substrate comprising deposited solid composition into the plurality of portions, thereby obtaining a plurality of said solid formulations for oral administration.

An apparatus for manufacturing a solid formulation for oral administration, said solid formulation comprising an edible substrate portion on which a first composition comprising a first pharmaceutical active ingredient is deposited, said apparatus comprising:

• a roller configured to provide a film comprising a plurality of edible substrate portions;
• a printer configured to spray, onto an edible substrate portion, a first liquid formulation comprising a first pharmaceutical active ingredient and a first solvent;
• a dryer configured to evaporate the first solvent so as to form a first solid composition deposited on the edible substrate portion;
• a nondestructive measuring device configured to measure a quantity Q of the first pharmaceutical active ingredient supported by an edible substrate portion without destroying the solid composition;
• and
• an electronic controller programmed to compare a measured quantity Q with a predetermined value Qref and control the printer to spray the first liquid formulation onto an edible substrate portion.