Compounds and methods for treating inflammation
AssigneesTufts Medical Center, Inc., Trustees of Tufts College, On Target Therapeutics LLC
InventorsCharles COHEN, Krishna KUMAR, Alan S. KOPIN, Benjamin N. HARWOOD, Venkata S. RAMAN, Pedram HAMRAH
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Abstract
The present disclosure relates to, among other things, compositions and methods for treating an inflammatory condition including, but not limited to, ocular inflammation, dry eye disease, and ocular neuropathic pain. One aspect of the present disclosure relates to a composition comprising (a) chemerin or a fragment or analog thereof and (b) a lipid entity linked to the chemerin or fragment or analog thereof.
Claims7
A method of decreasing corneal fluorescein staining in a human subject having dry eye disease, the method comprising topically administering to an eye of the human subject a therapeutically effective amount of a composition, thereby increasing tear film stability, wherein the composition comprises:
- a chemerin fragment consisting of the sequence of Y—F—P-G-Q-F-A-F—S(SEQ ID NO.:
- 2) or a chemerin analog consisting of the sequence of Y*—F-L-P—S*-Q-F-A*-Tic-S (SEQ ID NO.:
- 3), wherein * denotes D amino acids and Tic represents 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;
- a lipid entity selected from the group consisting of α-linolenic acid, γ-linolenic acid, palmitic acid, vaccenic acid, oleic acid, and elaidic acid;
- and
- a linker connecting the lipid entity to the chemerin fragment or chemerin analog.
Dependencies are inferred from the claim text.