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US 2022/0054547 A1Published application
Method of treating autoimmune and inflammatory diseases using b cells
AssigneeVersiti Blood Research Institute Foundation, Inc.
InventorBONNIE N. DITTEL
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Abstract
GITRL+ IgDlow/− B cells as well as methods of making and using said cells are described herein. Also described are methods for treating an autoimmune disease or an inflammatory condition in a subject in need there of using said B cells.
Claims21
A method for treating an autoimmune disease or an inflammatory condition in a subject in need thereof comprising:
- administering to the subject in need thereof a therapeutically effective amount of glucocorticoid-induced tumor necrosis factor receptor ligand positive (GITRL+), immunoglobulin D low (IgDlow) B cells.
An engineered B cell with increased GITRL expression and decreased IgD expression, the engineered B cell comprising a non-natural modification that increases expression of GITRL.
(canceled)
Dependencies are inferred from the claim text.