Novel therapeutic agent for inflammatory disease
AssigneesGachon University of Industry-Academic Cooperation Foundation, Eulji University Industry Academy Cooperation Foundation, Kyungpook National University Industry-Academic Cooperation Foundation
InventorsDongwoo KHANG, Jun-Young PARK, Youn Joo KANG, Sang-Hyun KIM, Song KWON
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Abstract
The present invention provides a novel therapeutic agent for treating inflammatory diseases which reduces the pro-inflammatory response and increases M2 macrophages according to the repolarization of macrophages, thereby exhibiting fewer side effects and excellent anti-inflammatory effects even at low doses compared to conventional steroid anti-inflammatory agent.
Claims15
A pharmaceutical composition for treating inflammatory disease comprising a gold nanoparticle-steroid complex in which a steroid anti-inflammatory agent is loaded on the surface of gold nanoparticle (AuNPs) coated with PEG by covalent or non-covalent bond as an active ingredient.
A method of treating inflammatory disease in a subject comprising administrating therapeutically effective amount of a gold nanoparticle-steroid complex in which a steroid anti-inflammatory agent is loaded on the surface of gold nanoparticle (AuNPs) coated with PEG by covalent or non-covalent bond to the subject.
Use of a gold nanoparticle-steroid complex in which a steroid anti-inflammatory agent is loaded on the surface of gold nanoparticle (AuNPs) coated with PEG by covalent or non-covalent bond in the manufacture of a therapeutic agent for treating inflammatory disease.
Dependencies are inferred from the claim text.