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US 2022/0054490 A1Published application
Hydantoin derivatives useful as kv3 inhibitors
AssigneeAutifony Therapeutics Limited
InventorsGiuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
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Abstract
The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
Claims18
A compound of formula (II):
- or a salt thereof;
- wherein:
- R1 is H, C1-4alkyl, halo, haloC1-4alkyl, CN, C1-4alkoxy, or haloC1-4alkoxy;
- R2 is H, C1-4alkyl, C3-4 spiro carbocyclyl, haloC1-4alkyl or halo;
- R3 is H, C1-4alkyl, haloC1-4alkyl or halo;
- A is a 5 or 6 membered saturated or unsaturated heterocycle, with at least one O atom;
- which heterocycle is optionally fused with a cyclopropyl group to form a tricycle when considered together with the phenyl;
- X is CH or N;
- Y is CH or N;
- R4 is C1-4alkyl;
- R5 is H, deuterium or C1-4alkyl;
- or R4 and R5 can be fused to form C3-4 spiro carbocyclyl.
9 more elements
Dependencies are inferred from the claim text.