Aurora kinase inhibitors
AssigneeThe Regents of the University of California
InventorsJustin Gabriel Meyerowitz, William Clay Gustafson, William A. Weiss, Nicholas T. Hertz, Kevan M. Shokat
Life of this patent
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Abstract
Disclosed herein inter alia are compositions and methods useful in the treatment of cancer and for modulating the activity of Aurora A kinase and/or a Myc family protein.
Claims13
-68. (canceled)
A method of inhibiting the level of activity of Aurora A kinase, comprising contacting Aurora A kinase with an effective amount of a compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the formula:
- wherein
- R1 is a substituted or unsubstituted C5 cycloalkyl, substituted or unsubstituted 5 membered heterocycloalkyl, or substituted or unsubstituted 5 to 6 membered heteroaryl;
- R2 is hydrogen, halogen, —CF3, —CCl3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCH3, —OCF3, —OCHF2, —C(O)CH3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- R3 is independently halogen, —CF3, —CCl3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCH3, —OCF3, —OCHF2, —C(O)CH3, unsubstituted alkyl, or unsubstituted heteroalkyl;
- and
- n is independently an integer from 0 to 5.
A method of treating a Myc family protein pathway-associated cancer in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound having the formula:
- wherein
- R1 is a substituted or unsubstituted C5 cycloalkyl, substituted or unsubstituted 5 membered heterocycloalkyl, or substituted or unsubstituted 5 to 6 membered heteroaryl;
- R2 is hydrogen, halogen, —CF3, —CCl3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCH3, —OCF3, —OCHF2, —C(O)CH3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- R3 is independently halogen, —CF3, —CCl3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCH3, —OCF3, —OCHF2, —C(O)CH3, unsubstituted alkyl, or unsubstituted heteroalkyl;
- and
- n is independently an integer from 0 to 5.
Dependencies are inferred from the claim text.