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US 2022/0054482 A1Published application
Method of providing aripiprazole to patients having impaired cyp2d6 or cyp3a4 enzyme function
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorArash Raoufinia
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Abstract
The disclosed embodiments relate to methods of initiating aripiprazole treatment in a patient who is a CYP2D6 poor metabolizer or a CYP3A4 poor metabolizer, or both.
Claims20
A method of initiating aripiprazole treatment in a patient with impaired CYP2D6 or CYP3A4 enzyme function, comprising:
- administering intramuscularly to said patient a starting dose of a long-acting drug-containing suspension which provides therapeutic plasma levels of aripiprazole over a period of about one month;
- wherein said starting dose provides no more than about 75% of the amount of aripiprazole compared to an initial dose recommended for a patient with normal CYP2D6 and CYP3A4 enzyme function.
Dependencies are inferred from the claim text.