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US 2022/0054480 A1Published application
Treatment of gliomas using organonitro compound combination therapy
AssigneeEpicentRx, Inc.
InventorsBryan T. Oronsky, Jan Scicinski
Life of this patent
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Abstract
The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.
Claims33
A method of treating a glioma in a patient, comprising the steps of:
- (a) administering to the patient in need thereof a therapeutically effective amount of a formulation comprising temozolomide, and within about 2 days thereafter subjecting the glioma to radiation therapy;
- and
- (b) administering to the patient at least one dose of a therapeutically effective amount of a formulation comprising ABDNAZ within about 7 days of administration of a first dose of the temozolomide;
- to treat the glioma;
- wherein each dose of the formulation comprising ABDNAZ is administered to the patient by intravenous infusion providing ABDNAZ in an amount of from about 0.1 mg to about 20 mg.
2 more elements
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A method of treating a glioma in a patient, comprising the steps of:
- (a) administering to the patient in need thereof a therapeutically effective amount of a formulation comprising irinotecan, and within about 7 days subjecting the glioma to radiation therapy;
- and
- (b) administering to the patient at least one dose of a therapeutically effective amount of a formulation comprising ABDNAZ within about 7 days of administration of a first dose of the irinotecan;
- to treat the glioma;
- wherein each dose of the formulation comprising ABDNAZ is administered to the patient by intravenous infusion providing ABDNAZ in an amount of from about 0.1 mg to about 20 mg.
2 more elements
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Dependencies are inferred from the claim text.