Methods of Treating Myeloproliferative Neoplasms
AssigneeKartos Therapeutics, Inc.
InventorWayne Rothbaum
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Abstract
Therapeutic methods and pharmaceutical compositions for treating a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis, are described. In certain embodiments, the invention includes therapeutic methods of treating a MPN using a combination of a compound of Formula (I) or Formula (II) with a therapeutic agent selected from the group consisting of a JAK inhibitor, an IDH inhibitor, a PD-1 inhibitor, a PD-L1 inhibitor, a PD-L2 inhibitor, an interferon, a PI3K inhibitor, an AKT inhibitor, an mTOR inhibitor, a nucleoside analog, and combinations thereof.
Claims30
A method of treating a myeloproliferative neoplasm (MPN) comprising administering to a human in need thereof, therapeutically effective amounts of a MDM2 inhibitor in combination with a therapeutic agent, wherein the MDM2 inhibitor is a compound of Formula (I) or a compound of Formula (II):
- or a pharmaceutically acceptable salt thereof, wherein the therapeutic agent is selected from the group consisting of a JAK inhibitor, an IDH inhibitor, a PD-1 inhibitor, a PD-L1 inhibitor, a PD-L2 inhibitor, an interferon, a PI3K inhibitor, an AKT inhibitor, an mTOR inhibitor, a nucleoside analog, and combinations thereof.
17-25. (canceled)
27-32. (canceled)
43-84. (canceled)
Dependencies are inferred from the claim text.