Salivary gland regeneration
AssigneesCase Western Reserve University, The Regents of the University of California
InventorsSarah Knox, Chelsea S. Bahney, Eben Alsberg, Oju Jeon
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Abstract
A method is provided for promoting salivary gland regeneration in a subject in need thereof comprising administering to acinar progenitor cells of the salivary gland at least one of a cholinergic agonist or muscarinic agonist to promote acinar cell generation. In particular, formulations comprising a muscarinic agonist such as cevimeline encapsulated in an alginate hydrogel can be formulated for local administration to a salivary gland and used in treatment of xerostomia.
Claims55
A composition comprising a muscarinic agonist encapsulated in a hydrogel formulated for local administration to a salivary gland for use in the treatment of Xerostomia.
A method of promoting salivary gland regeneration in a subject in need thereof, the method comprising:
- administering locally to acinar progenitor cells and acinar cells of the salivary gland at least one of a cholinergic agonist or muscarinic agonist to promote proliferation of the acinar progenitor cells and the acinar cells and thereby increase saliva production.
Dependencies are inferred from the claim text.