Kchip2 modulator compounds and their use for the treatment of cardiovascular diseases

A method of treatment of heart diseases in a subject, wherein the treatment comprises administering to said subject an effective amount of a compound of formula (I):

• wherein:
• R1 and R2 are independently selected from H, OH, —O-aryl, halogen, aryl or heteroaryl, wherein the aryl or heteroaryl groups are optionally substituted with (C1-C6) alkyl, —OH, (C3-C6) cycloalkyl, —O—(C1-C6) alkyl or halogen;
• n has a value of 1 or 2;
• Ar is selected from the following groups:
• wherein R3 is selected from —OH or —O—(C1-C6)-alkyl;
• R4 is selected from H, halogen, —O—(C1-C6)-alkyl, phenyl optionally substituted with (C1-C6) alkyl;
• R5 is selected from H or phenyl optionally substituted with alkyl (C1-C6), or the salts, isomers or solvates thereof, and wherein the heart diseases are selected from heart arrhythmia myocardial ischemia, myocardial infarction, cardiac hypertrophy or cardiomyopathy.