Nmda receptor antagonist formulation with reduced neurotoxicity
AssigneeStuart L. Weg
InventorsFred H. Mermelstein, Randi Albin
Life of this patent
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Abstract
The present invention is directed to pharmaceutical compositions of effective amounts of NMDA receptor antagonists and preservative for the administration to a patient in need of effective analgesia and anesthesia. The compositions of the invention advantageously do not cause any significant neurotoxicity. The preferred NMDA receptor antagonist is ketamine. The preferred preservative is benzalkonium chloride.
Claims21
1-20. (canceled)
A pharmaceutical composition consisting of:
- about 10% ketamine hydrochloride, about 0.002% benzalkonium chloride, and a carrier selected from the group consisting of saline, aqueous sodium bicarbonate, and water;
- wherein the formulation is adapted for once daily administration;
- wherein the composition does not cause any significant neurotoxicity, and
- wherein the level of neurotoxicity is comparable to sterile water when administered.
A method of treating breakthrough pain, comprising administering a pharmaceutical composition consisting of a therapeutically effective amount of ketamine hydrochloride, about 0.002% benzalkonium chloride, and a carrier selected from the group consisting of saline, aqueous sodium bicarbonate, and water, to a subject;
- wherein the subject has been diagnosed with chronic malignant pain.
A method of delivering ketamine through a nasal spray, comprising:
- administering to a nostril of a subject a number of sprays of a pharmaceutical composition;
- wherein the pharmaceutical composition consists of a therapeutically effective amount of ketamine hydrochloride, about 0.002% benzalkonium chloride, and a carrier selected from the group consisting of saline, aqueous sodium bicarbonate, and water;
- wherein the composition does not cause any significant neurotoxicity;
- wherein the composition has a level of neurotoxicity is comparable to sterile water when administered.
Dependencies are inferred from the claim text.