Compositions comprising cannabidiol and second therapeutic agents for the treatment of cancer
AssigneeJay Pharma Inc.
InventorsIlana NATHAN, Zvi VOGEL, Lakshmi Narasaiah UPPALAPATI, Adela Juknat GERALNIK
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Abstract
The invention provides synergistic combinations of cannabidiol (CBD) and a second therapeutic agent, such as one or more ChEH/AEBS inhibitors, a naphthoquinone or a derivative thereof, or any combination thereof, effective for the treatment cancer. Compositions containing same and methods of use of same are described.
Claims26
1-55. (canceled)
A method of treating cancer comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising:
- a synergistic combination of cannabidiol (CBD) and at least one cholesterol epoxide hydrolase/anti-estrogen binding site (ChEH/AEBS) inhibitor compound, wherein the ChEH/AEBS inhibitor compound is a selective estrogen receptor modulator (SERM);
- and
- a pharmaceutically acceptable carrier.
A composition comprising a synergistic combination of cannabidiol (CBD) and at least one cholesterol epoxide hydrolase/anti-estrogen binding site (ChEH/AEBS) inhibitor compound, which ChEH/AEBS inhibitor compound is not a selective estrogen receptor modulator (SERM) and is a selective inhibitor of ChEH/AEBS, wherein the CBD is present in an amount sufficient to provide a dose of 0.1 mg/kg to 50 mg/kg to a subject and the ChEH/AEBS inhibitor compound is present in an amount sufficient to provide a dose of 500 mg/kg to 2000 mg/kg to the subject, and the selective inhibitor is 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-Pyrrolidine (PBPE) or tesmilifene (DPPE).
A composition comprising a synergistic combination of cannabidiol (CBD) and at least one naphthoquinone or a derivative thereof.
Dependencies are inferred from the claim text.