Subcutaneous administration of nanoparticles comprising an mtor inhibitor and albumin for treatment of diseases
AssigneeAbraxis BioScience, LLC
InventorsNeil P. DESAI, Shihe HOU
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Abstract
The present invention provides compositions and devices for subcutaneously administering compositions comprising nanoparticles comprising an mTOR inhibitor and an albumin. The present application also provides methods of treating diseases by subcutaneously administering to an individual a composition comprising nanoparticles comprising an mTOR inhibitor and an albumin.
Claims34
A method of treating a disease in an individual, comprising subcutaneously administering to the individual a pharmaceutical composition comprising nanoparticles comprising an mTOR inhibitor and an albumin, wherein the amount of the mTOR inhibitor in the pharmaceutical composition is at a dose of about 0.1 mg/m2 to about 10 mg/m2 for each administration.
A method of delivering an effective amount of an mTOR inhibitor to a target tissue of an individual, the method comprising subcutaneously administering a pharmaceutical composition comprising nanoparticles comprising an mTOR inhibitor and an albumin.
A pharmaceutical composition suitable for subcutaneous administration to an individual comprising:
- a) nanoparticles comprising an mTOR inhibitor and an albumin, and b) a saccharide.
A device for subcutaneously administering to an individual a pharmaceutical composition comprising nanoparticles comprising an mTOR inhibitor and an albumin, the device comprising:
- a) a drug chamber containing a dried form of the pharmaceutical composition, and a solution chamber containing a reconstituting solution:
- b) a removable divider separating the drug chamber and the solution chamber, wherein removal of the divider causes mixing of the dried pharmaceutical composition and reconstituting solution, thereby forming a reconstituted pharmaceutical composition.
Dependencies are inferred from the claim text.