Sprayable polymers as adhesion barriers
AssigneeAra Medical LLC
InventorsDonald J. EATON, Bin HUANG, Michael A. SAVITT
Life of this patent
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Abstract
A formulation for generating an adhesion barrier that includes a plurality of particles or a dry powder that is made of a polymer combination of at least one biodegradable polymer and at least one water soluble polymer is disclosed. Methods of making and delivering the formulation are further disclosed. The formulation of particles is deposited on a surface of internal body tissue and the deposited formulation absorbs moisture from the tissue and forms a film over the surface. The film acts as an adhesion barrier by reducing or preventing adhesion of the surface to other body tissue.
Claims22
1-27. (canceled)
A formulation for generating an adhesion barrier film comprising:
- a plurality of particles comprising:
- a combination of poly(L-lactide-co-glycolide) (PLGA) and alginate,
- a combination of PLGA and polyvinylpyrrolidone (PVP),
- a combination of PLGA and poly(vinyl) alcohol (PVA),
- a combination of PLGA and chitosan, or
- a combination of chitosan and PVA;
- wherein:
- the formulation is in the form of a dry powder,
- the mean particle size is between about 700 nm and about 200 microns;
- and
- when the formulation is deposited on a surface of internal body tissue the deposited formulation absorbs moisture from the tissue and forms an adhesion barrier film configured to be adhered to the surface, wherein the film is capable of reducing or preventing adhesion of the surface to other body tissue.
Dependencies are inferred from the claim text.