Biomaterial based on aligned fibers, arranged in a gradient interface, with mechanical reinforcement for tracheal regeneration and repair

A fibrous scaffold comprising:

• a first type of polymeric electrospun fiber;
• and
• a second type of polymeric electrospun fiber;
• wherein at least one of the first type of polymeric electrospun fiber and the second type of polymeric electrospun fiber comprise a polymer selected from the group consisting of polyglycolic acid, poly(lactic-co-glycolic acid), poly(L-lactide-co-caprolactone), and polycaprolactone;
• and
• wherein the first type of polymeric electrospun fiber and the second type of polymeric electrospun fiber are co-electrospun.

A tubular fibrous scaffold having an inner surface and an outer surface, the tubular fibrous scaffold comprising:

• a first section and a second section, wherein the first second and the second section have a gradient interface;
• wherein the first section comprises the inner surface, and wherein the second section comprises the outer surface;
• and
• wherein the first section comprises a plurality of biodegradable polymeric electrospun fibers, and wherein the second section comprises a plurality of biostable polymeric electrospun fibers.