Balloon catheter system assisted by ultrasound and microbubbles and method for vasodilation

A method for vasodilation, comprising:

• providing a sensor catheter into a blood vessel, and controlling a highly focused ultrasound probe to focus at a hardened portion of the blood vessel;
• removing the sensor catheter from the blood vessel and inserting a balloon catheter into the blood vessel;
• infusing microbubbles into the balloon catheter and controlling the highly focused ultrasound probe to start working to destroy a calcification point of the hardened portion of the blood vessel;
• and
• smoothly inflating the balloon catheter at the hardened portion of the blood vessel.

A balloon catheter system assisted by ultrasound and microbubbles, comprising:

• a controller;
• a balloon catheter;
• and
• at least one ultrasound transducer, wherein the ultrasound transducer is located within the balloon catheter, and the ultrasound transducer is connected to the controller.

A method for vasodilation, comprising:

• providing a balloon catheter into a blood vessel;
• infusing microbubbles into the balloon catheter and controlling an ultrasound transducer to start working to destroy the microbubbles and generate shock waves;
• and
• smoothly inflating the balloon catheter at a hardened portion of the blood vessel.

A microbubble solution composition, comprising three materials of:

• 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC);
• 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-5000] (DSPE-PEG 5000);
• and
• 1,2-distearoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (DSPG),
• wherein a weight ratio of the three materials is 2.5:1:1, and the three materials are dissolved in a combination of one or more of dichloromethane, chloroform, acetonitrile, methanol, or ethyl acetate, and followed by heating up and vortex mixing.