Device and method for treatment of deep vein thrombosis and pulmonary embolism

A method of capturing a thrombus within vasculature comprising providing an intravascular thrombus retraction device comprised of wires that are compressible into a compact cylindrical form within a catheter and which are self-expandable into a wire mesh web with at least some parallel wires forming openings in the wire mesh sufficient to allow fluid passage and small enough to filter particles of at least 0.001 mm, a base of the wire mesh web connected to radially ring-shaped structure supporting and maintaining an opening in the base of the wire mesh and forming a thrombus capture volume, the ring-shaped structure being compressible into the catheter and being self-expandable when free of compressive forces within the catheter to open up into the open, expanded ring-shaped structure, maintaining the opening in the opening in the base of the wire mesh, multiple intermediate guide wires are connected to and spaced about the ring-shaped structure, the multiple intermediate guide wires are connected to withdrawal guidewires extending into the catheter, at least some of the wires in the wire mesh having protrusions extending inwardly into the thrombus capture volume, at least some of the protrusions having a height less than a distance between the at least some parallel wires;

• the method comprising:
• a) inserting the device into a blood vessel having a thrombus;
• b) advancing a distal end of the catheter of the device towards a thrombus;
• c) deploying the compressed wire mesh and ring-shaped structure distally past the thrombus;
• d) expanding the wire mesh and ring-shaped structure past the thrombus;
• e) retracting the wire mesh and ring-shaped structure by applying tension to the withdrawal guidewires in a first retraction step;
• and
• f) capturing the thrombus within the wire mesh during the first retraction step.

A method of treating deep vein thrombosis and pulmonary embolisms comprising accessing a venous vessel of a patient, inserting a retraction catheter containing an intravascular thrombus retraction device comprised of wires that are compressible into a compact cylindrical form within a catheter and which are self-expandable into a wire mesh web with at least some parallel wires forming openings in the wire mesh sufficient to allow fluid passage and small enough to filter particles of at least 0.001 mm, a base of the wire mesh web connected to radially ring-shaped structure supporting and maintaining an opening in the base of the wire mesh and forming a thrombus capture volume, the ring-shaped structure being compressible into the catheter and being self-expandable when free of compressive forces within the catheter to open up into the open, expanded ring-shaped structure, maintaining the opening in the opening in the base of the wire mesh, multiple intermediate guide wires are connected to and spaced about the ring-shaped structure, the multiple intermediate guide wires are connected to withdrawal guidewires extending into the catheter, at least some of the wires in the wire mesh having protrusions extending inwardly into the thrombus capture volume, at least some of the protrusions having a height less than a distance between the at least some parallel wires into the venous circulatory system to a site of clot, inserting an aspiration catheter with wall-mounted suction attached to an inflow port of the aspiration catheter, removing clot and other debris from the venous vessel, and removing both soft and hard components of a vascular obstruction with one pass over a volume that contained both hard components and soft components of the clot and other debris.