Systems and methods for denoising physiological signals during electrical neuromodulation

A denoising system for denoising an ECG waveform, the system comprising:

• an ECG electrode array configured to obtain ECG signals from a patient;
• one or more processors configured to be communicatively coupled to the ECG electrode array, the one or more processors configured to, upon execution of stored instructions on a non-transitory computer-readable medium:
• determine whether an ECG signal received from the ECG electrode array comprises transitory noise caused by application of electrical stimulation by an electrical stimulation device;
• if it is determined that the ECG signal does not comprise transitory noise caused by application of electrical stimulation by the electrical stimulation device,
• cause the ECG signal to be output for display on the patient monitor without modifying the ECG signal;
• and
• if it is determined that the ECG signal comprises transitory noise caused by application of electrical stimulation by an electrical stimulation device,
• digitize the ECG signal using an analog-to-digital converter;
• denoise the digitized ECG signal, wherein denoising the digitized ECG signal comprises removing values in memory locations corresponding to portions of the digitized ECG signal having the transitory noise and interpolating the portions of the digitized ECG signal having the transitory noise to replace the removed values with modified values based on said interpolating to create a denoised ECG signal;
• convert the denoised ECG signal to an analog signal using a digital-to-analog converter;
• and
• output the denoised ECG signal for display on a patient monitor.

A denoising system for denoising an ECG signal comprising transitory noise caused by application of electrical stimulation by a stimulation device, the denoising system being communicatively coupled to an ECG electrode array configured to obtain ECG signals from a patient, the denoising system comprising:

• circuitry configured to:
• detect portions of the ECG signal comprising the transitory noise by identifying portions of the ECG signal corresponding to time periods when a synchronization signal is received from an electrical stimulation system indicative of electrical stimulation being administered;
• and
• denoise the detected portions of the ECG signal comprising the transitory noise, wherein denoising the detected portions of the ECG signal comprises blanking the detected portions of the ECG signal comprising the transitory noise and modifying the blanked portions to provide a modified ECG signal with reduced transitory noise.

A denoising system for removing a transitory noise from a digitized biopotential of a living being, said transitory noise generated synchronous with electrical stimulation of a portion of a body of the living being, said system comprising one or more processors configured to, upon execution of instructions stored on a non-transitory computer-readable medium:

• receive a synchronization signal from an electrical stimulation system indicative of timing of the electrical stimulation;
• remove said transitory noise from the digitized biopotential based upon receipt of the received synchronization signal;
• and
• interpolate across a gap created in the digitized biopotential to create a digitized biopotential free of transitory noise.