Nanophotonic sensor implants with 3d hybrid periodic-amorphous photonic crystals for wide-angle monitoring of long-term in-vivo intraocular pressure field

Abstract

A biosensor includes a periodic crystalline structure first layer, and an amorphous crystalline structure second layer. The first and second layers are formed from a biocompatible silicone having a Young's Modulus E between 0.4 and 2.0 MPa. The biosensor has a pressure dependent NIR resonance peak shift of less than 15 nm over a field of view of 40°, and has an optical pressure sensitivity of between 0.38 and 2.6 nm/mm Hg. The biosensor may be formed by forming a 3D crystalline structure having a periodic amorphous crystalline first layer and an amorphous crystalline second layer. Voids of the 3D crystalline structure are filled with the biocompatible silicone/polydimethylsiloxane a material. The 3D crystalline structure is removed to form an inverse structure having a first volume of an amorphous arrangement of voids and a second volume of a periodic arrangement of voids.

Dependencies are inferred from the claim text.