Brain Activation Matching

A system comprising:

• a. a psychophysiological response sensor subsystem comprised of at least one of a psychophysiological response sensor selected from at least one of a psychophysiological sensor types and combinations thereof to observe and record at least one of a psychophysiological response measure resulting from evoked and spontaneous brain activity;
• b. a computing device comprising a processor in communication with said psychophysiological response sensor subsystem;
• c. a non-transitory, computer-readable medium in communication with said processor and storing instructions that, when executed by said processor, cause said processor to perform operations comprising:
• d. a sequence of stimuli comprised of at least one of a stimulus element of at least one of a stimulus type:
• e. a set of sequences of stimuli:
• f. presenting by a sensory presentation device a first sequence of stimuli to:
• (i) a first set of subjects associated with a first selection criteria and (ii) a second set of subjects associated with a second selection criteria;
• g. detecting a first set of psychophysiological response data sequences, said first set of psychophysiological response data sequences comprising a sequence of psychophysiological response measures of interest from each of said first set of subjects;
• h. detecting a second set of psychophysiological response data sequences, said second set of psychophysiological response data sequences comprising a sequence of psychophysiological response measures of interest from each of said second set of subjects;
• i. determining, by a first data processing means, a brain activation signature for said first set of subjects comprised of a pattern of psychophysiological response data sequences characteristic of said first set of psychophysiological response data sequences and not characteristic of the second set of psychophysiological response data sequences;
• and
• j. extracting a brain activation template comprising a digital representation of the distinctive characteristics of said brain activation signature for said first set of subjects and store in the computing device.