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US 2022/0053740 A1Published application
A genetic mouse model of autoimmune adverse events and immune checkpoint blockade therapy
AssigneeBoard of Regents, The University of Texas System
InventorsSpencer WEI, James ALLISON
Life of this patent
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Abstract
Provided herein are mice that are heterozygous knock outs for Ctla4 and homozygous knockouts for Pdcd1 (Ctla4+/− Pdcd1−/− mice), which may suffer from autoimmunity, including myocarditis and insulin-dependent diabetes mellitus. Also provided are methods of using such mice to screen for therapeutic agents that mitigate immune-related adverse events.
Claims49
A mouse whose genome comprises:
- (i) a heterozygous loss-of-function allele of a Ctla4 gene and (ii) a homozygous loss-of-function allele of a Pdcd1 gene.
Dependencies are inferred from the claim text.