Novel sting agonists

A method of treating a disorder, disease, syndrome, or condition, wherein said disorder, disease, syndrome, or condition is affected by the agonism of STING, comprising administering to a subject in need thereof a therapeutically effective amount of the compound, or pharmaceutically acceptable salt of a compound of Formula I′ having the structure:

• or a pharmaceutically acceptable salt thereof, wherein:
• W is absent or independently selected from O, S or —NR6;
• X is CH2, O or S;
• Y is absent or independently selected from O, S or —NR7;
• Q1 and Q2 are each independently O or S;
• is a 5- to 6-membered monocyclic heteroaryl or a 7- to 12-membered bicyclic heteroaryl;
• both of which are optionally substituted with R10 and R11 and wherein the 7- to 12-membered bicyclic heteroaryl contains at least two N atoms;
• Z is independently selected from C1-C6 alkyl, halo-C1-C6-alkyl and C3-C6 cycloalkyl;
• Z1 is independently selected from C1-C6 alkyl, halo-C1-C6-alkyl and C3-C6 cycloalkyl;
• Z2 is independently selected from C1-C4 alkyl and halo-C1-C4-alkyl;
• R1 is a 5- to 6-membered monocyclic heteroaryl or a 7- to 10-membered bicyclic heteroaryl;
• both of which are optionally substituted with R12 and R13 and wherein the 7- to 10-membered bicyclic heteroaryl contains at least two N atoms;
• R2 is independently selected from H, halo, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl, halo-C1-C4 alkoxy, CN, —NR8R9, C3-C4 cycloalkyl and OH;
• R3 is independently selected from H, halo, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl, halo-C1-C4 alkoxy, CN, and OH;
• or R2 and R3 can be taken together with the carbon to which they are attached to form a C3-C4 cycloalkyl ring;
• R4 is selected from OH, SH, C1-C6 alkoxy-carbonyl-oxy-C1-C6 alkoxy, C1-C6 alkoxy-carbonyl-oxy-C1-C6 alkylthio, and BH3;
• R5 is selected from OH, SH, C1-C6 alkoxy-carbonyl-oxy-C1-C6 alkoxy, C1-C6 alkoxy-carbonyl-oxy-C1-C6 alkylthio, and BH3;
• R6 is independently selected from H, C1-C4 alkyl, C2-C3 alkenyl, C2-C3 alkynyl, C3-C6 cycloalkyl and C1-C4 alkoxy;
• R7 is independently selected from H, C1-C4 alkyl, C2-C3 alkenyl, C2-C3 alkynyl, C3-C6 cycloalkyl and C1-C4 alkoxy;
• R8 is independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4-alkyl, —C(═O)R15 and —SO2R15;
• R9 is independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, and halo-C1-C4-alkyl;
• R10 is independently selected from H, ═O, halo, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl, halo-C1-C4 alkoxy, CN, —NR14R15, —NR14C(═O)R15, —C(═O)NR14R15, a C6-C10 aryl, a 5- to 10-membered heteroaryl, a 4- to 6-membered heterocycloalkyl, a C3-C6 cycloalkyl, SR18 and OH;
• wherein the C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl, halo-C1-C4 alkoxy, C6-C10 aryl, the 5- to 10-membered heteroaryl and the C3-C6 cycloalkyl are each optionally substituted with OH, 1 to 3 halo, CN, —NR14R15, —C(═O)NR14R15, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl and halo-C1-C4 alkoxy;
• R11 is independently selected from H, ═O, halo, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl, halo-C1-C4 alkoxy, CN, —NR14R15, —NR14C(═O)R15, —C(═O)NR14R15, a C6-C10 aryl, a 5- to 10-membered heteroaryl, a 4- to 6-membered heterocycloalkyl, a C3-C6 cycloalkyl, SR18 and OH;
• wherein the C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl, halo-C1-C4 alkoxy, C6-C10 aryl, the 5- to 10-membered heteroaryl and the C3-C6 cycloalkyl are optionally substituted with OH, 1 to 3 halo, CN, —NR14R15, —C(═O)NR14R15, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl and halo-C1-C4 alkoxy;
• R12 is independently selected from H, ═O, halo, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl, halo-C1-C4 alkoxy, CN, —NR16R17, —NR16C(═O)R17, a C6-C10 aryl, a 5- to 10-membered heteroaryl and OH;
• R13 is independently selected from H, ═O, halo, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkyl, halo-C1-C4 alkoxy, CN, —NR16R17, —NR16C(═O)R17, a C6-C10 aryl, a 5- to 10-membered heteroaryl and OH;
• R14, at each occurrence, is independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4-alkyl, —C(═O)R18 and —SO2R15;
• R15, at each occurrence, is independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4-alkyl, a C6-C10 aryl and a 5- to 10-membered heteroaryl;
• R16, at each occurrence, is independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4-alkyl, —C(═O)R17 and —SO2R17;
• R17, at each occurrence, is independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4-alkyl, a C6-C10 aryl, and a 5- to 10-membered heteroaryl;
• and
• R18 is selected from H and C1-C4 alkyl.