Back to results
US 2022/0048849 A1Published application
Decarboxylase inhibitors for treating parkinson's disease
AssigneeSenda Biosciences, Inc.
InventorsDevin Forest Reed DOUD, Timothy BRIGGS, Steven TAYLOR, Elijah BOGART, John PROUDFOOT, Dinara Shashanka GUNASEKERA, Spencer Cory PECK, Angela SHE, William MCELROY, Bernard LANTER, Michael RUTLIN
Life of this patent
Estimating the term…
Abstract
Provided are inhibitors of pathogenic, bacterial metabolite production and conjugates of the inhibitors. Also provided are pharmaceutical compositions containing the inhibitors or conjugates and methods of using the same.
Claims28
A compound chosen from the following compounds
- and pharmaceutically acceptable salts thereof.
A compound chosen from the following compounds
- and pharmaceutically acceptable salts thereof.
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein
- n is 0 or 1;
- R1 is H or —ORA, wherein RA is H, —C(O)C1-6 alkyl, or an acylated sugar;
- R2 is H, halogen, amino, C1-6 alkyl, or —ORA, wherein RA is H or an acylated sugar;
- R3 is H, a halogen, —OH, or C1-6 alkyl optionally substituted with one or more halogens;
- R4 is H, —NH2, —C(O)OCH3, or an acylated sugar;
- R5 is H, —C(O)OH, —C(O)OC1-6 alkyl, —C(O)Oglycoside, —C(O)NHOH, or —C(O)O(acylated sugar);
- and
- R6 is H, halogen, or optionally substituted C1-6 alkyl;
- provided that at least one RA is present;
- or provided that R3 and/or R6 comprise a halogen.
9 more elements
Dependencies are inferred from the claim text.