African swine fever virus vaccine
AssigneeStichting Wageningen Research
InventorsPetrus Theodorus Johannes Willemsen, Bernardus Petrus Hubertus Peeters
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Abstract
The invention is directed to a recombinant nucleic acid molecule comprising an expression cassette encoding a polyepitope comprising T-cell antigens from proteins of African Swine Fever Virus. The invention further relates to a viral particle, comprising said recombinant nucleic acid molecule, and to a viral particle comprising B-cell antigens of African Swine Fever Virus. The invention further relates to methods of stimulating an immune response in a pig comprising administering the recombinant molecule of the invention, and/or the viral particle of the invention, to the pig in an amount effective to induce an immune response.
Claims18
A recombinant nucleic acid molecule, preferably recombinant DNA molecule, comprising an expression cassette encoding a polyepitope comprising T-cell antigens from proteins of African Swine Fever Virus, wherein the T-cell antigens are separated by spacers, preferably by spacers of 1-10 amino acid residues, that contain signals for proteasome cleavage.
Dependencies are inferred from the claim text.