# US 2022/0044402 A1 · Methods, systems, and devices for analyzing lung imaging data to determine collateral ventilation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2022/0044402 A1 - Document ID: US20220044402A1 - Status: Published application - Kind: A1 - Application number: 17/444,336 - Filed: 2021-08-03 - Published: 2022-02-10 - Earliest claimed: 2020-08-06 - Assignees: Pulmonx Corporation - Applicants: Pulmonx Corporation - Inventors: Sri Radhakrishnan; Ryan Olivera - Web page: https://patentgrep.com/patent/US20220044402A1 ## CPC - G06T 7/0012: {Biomedical image inspection} - A61B 6/032: {Transmission computed tomography [CT]} - A61B 6/50: specially adapted for specific body parts; specially adapted for specific clinical applications - A61B 6/5217: {extracting a diagnostic or physiological parameter from medical diagnostic data} - G06T 7/11: Region-based segmentation - G16H 15/00: ICT specially adapted for medical reports, e.g. generation or transmission thereof - G16H 30/20: for handling medical images, e.g. DICOM, HL7 or PACS - G16H 30/40: for processing medical images, e.g. editing - G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems - G16H 50/30: for calculating health indices; for individual health risk assessment - G06T 2207/10081: Computed x-ray tomography [CT] - G06T 2207/30061: Lung - G16H 20/40: relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract Devices, methods, and systems are provided for analyzing lung imaging data. Lung imaging data maybe analyzed to segment the lung, identify fissure locations, calculate fissure defect scores, identify adjacent lung compartments, calculate emphysema scores, calculate volumes, and calculate proximities. Collateral ventilation within a lung compartment may be determined based on the analyzed lung imaging data. ## Claims ### Claim 1 A method of assessing collateral ventilation in a lung of a patient, the method comprising: analyzing computerized tomography data of a lung, wherein analyzing the computerized tomography data comprises segmenting the lung into separate lung compartments; calculating an emphysema score for one or more regions of one or more lung compartments based on a density mask; identifying a fissure defect; calculating a fissure defect score based on a size of the fissure defect; determining a proximity of the fissure defect to the region of the lung compartment; and determining whether collateral ventilation is present or above a threshold level in the lung compartment based on the calculated emphysema score, fissure defect score, and the proximity of the fissure defect to the region of the lung compartment. ### Claim 2 (depends on 1) The method of claim 1, wherein collateral ventilation is determined to be present or above a threshold level if the region of the lung compartment has an emphysema score above a threshold emphysema score value, that the fissure defect has a fissure defect score above a threshold fissure defect score value, and that the proximity of the fissure defect to the region of the lung compartment is within a threshold proximity. ### Claim 3 (depends on 1) The method of claim 1, further comprising calculating a collateral ventilation score for the lung compartment based on the emphysema score, fissure defect score, and proximity of the fissure defect to the region of the lung compartment; wherein determining whether collateral ventilation is present or above a threshold level in the lung compartment is based on the calculated collateral ventilation score. ### Claim 4 (depends on 3) The method of claim 3, comprising determining a degree of collateral ventilation based on the calculated collateral ventilation score. ### Claim 5 (depends on 1) The method of claim 1, further comprising creating a report indicating lung compartments determined to have collateral ventilation or degrees of collateral ventilation for lung compartments. ### Claim 6 (depends on 5) The method of claim 5, wherein the report comprises one or more potential treatment sites and one or more suggested implantable devices for the potential treatment site to cause lung volume reduction or reduce hyperinflation; wherein the lung compartment is determined not to have collateral ventilation or a degree of collateral ventilation below a threshold level and the potential treatment site is an airway leading to the lung compartment. ### Claim 7 (depends on 5) The method of claim 5, wherein the report comprises one or more potential treatment sites and one or more suggested therapeutic agents or implantable devices to be delivered to the potential treatment site to cause lung volume reduction or reduce hyperinflation; wherein the lung compartment is determined to have collateral ventilation or a degree of collateral ventilation above a threshold level and the potential treatment site comprises one or more regions within the lung compartment. ### Claim 8 (depends on 5) The method of claim 5, wherein the report comprises one or more potential treatment sites and one or more suggested therapeutic agents or implantable devices to be delivered to the potential treatment site to minimize collateral ventilation between lung compartments; wherein the lung compartment is determined to have collateral ventilation or a degree of collateral ventilation above a threshold level and the potential treatment site comprises an airway leading to the fissure defect. ### Claim 9 (depends on 1) The method of claim 1, wherein determining whether collateral ventilation is present or above a threshold level in the lung compartment is further based on which fissure comprises the fissure defect, where on the fissure the fissure defect is located, or which lung compartments the fissure defect separates. ### Claim 10 (depends on 1) The method of claim 1, further comprising identifying airways; wherein determining whether collateral ventilation is present or above a threshold level in the lung compartment is based on whether an airway is identified within a threshold proximity to the region of the lung compartment. ### Claim 11 (depends on 1) The method of claim 1, further comprising identifying airways; wherein determining whether collateral ventilation is present or above a threshold level in the lung compartment is based on whether an airway is identified within a threshold proximity to the fissure defect. ### Claim 12 A method of assessing collateral ventilation in a lung of a patient, the method comprising: analyzing computerized tomography data of a lung, wherein analyzing the computerized tomography data comprises: segmenting the lung into separate lung compartments; identifying a fissure defect; identifying lung compartments adjacent to the fissure defect; calculating emphysema scores for one or more regions of a first lung compartment adjacent to the fissure defect and for one or more regions of a second lung compartment adjacent to the fissure defect on an opposing side of the fissure defect based on a density mask; calculating a fissure defect score based on a size of the fissure defect; determining proximities of the fissure defect to the region of the first lung compartment and the region of the second lung compartment; and determining whether collateral ventilation is present or above a threshold level in the first or second lung compartment based on the calculated emphysema score, fissure defect score, and the proximities of the fissure defect to the region of the first and second lung compartments. ### Claim 13 (depends on 12) The method of claim 12, wherein collateral ventilation is determined to be present or above a threshold level if the region of the first lung compartment has an emphysema score above a threshold emphysema score value, the region of the second lung compartment has an emphysema score above a threshold emphysema score value, the fissure defect has a fissure defect score above a threshold fissure defect score value, the proximity of the fissure defect to the region of the first lung compartment is within a threshold proximity, and the proximity of the fissure defect to the region of the second lung compartment is within a threshold proximity. ### Claim 14 (depends on 12) The method of claim 12, further comprising calculating a collateral ventilation score for the first or second lung compartment based on the emphysema scores of the regions of the first and second lung compartments, fissure defect score, and proximities of the fissure defect to the regions of the first and second lung compartments; wherein determining whether collateral ventilation is present or above a threshold level in the first or second lung compartment is based on the calculated collateral ventilation score. ### Claim 15 (depends on 14) The method of claim 14, comprising determining a degree of collateral ventilation based on the calculated collateral ventilation score. ### Claim 16 (depends on 12) The method of claim 12, further comprising creating a report indicating lung compartments determined to have collateral ventilation or degrees of collateral ventilation for lung compartments. ### Claim 17 (depends on 16) The method of claim 16, wherein the report comprises one or more potential treatment sites and one or more suggested implantable devices for the potential treatment site to cause lung volume reduction or reduce hyperinflation; wherein the first or second lung compartment is determined not to have collateral ventilation or a degree of collateral ventilation below a threshold level and the potential treatment site is an airway leading to the first or second lung compartment. ### Claim 18 (depends on 16) The method of claim 16, wherein the report comprises one or more potential treatment sites and one or more suggested therapeutic agents or implantable devices to be delivered to the potential treatment site to cause lung volume reduction or reduce hyperinflation; wherein the first or second lung compartment is determined to have collateral ventilation or a degree of collateral ventilation above a threshold level and the potential treatment site comprises one or more regions within the first or second lung compartment. ### Claim 19 (depends on 16) The method of claim 16, wherein the report comprises one or more potential treatment sites and one or more suggested therapeutic agents or implantable devices to be delivered to the potential treatment site to minimize collateral ventilation between lung compartments; wherein the first or second lung compartment is determined to have collateral ventilation or a degree of collateral ventilation above a threshold level and the potential treatment site comprises an airway leading to the fissure defect. ### Claim 20 A method of assessing collateral ventilation in a lung of a patient, the method comprising: analyzing computerized tomography data of a lung, wherein analyzing the computerized tomography data comprises segmenting the lung into separate lung compartments; identifying a fissure defect; identifying lung compartments adjacent to the fissure defect; determining changes in volumes of a first lung compartment adjacent to the fissure defect and second lung compartment adjacent to the fissure defect on an opposing side of the fissure defect during breathing; and determining whether collateral ventilation is present or above a threshold level in the first or second lung compartment based on the changes in volumes of the first and second lung compartments. ### Claim 21 (depends on 20) The method of claim 20, wherein collateral ventilation is determined to be present or above a threshold level if the first and second lung compartments inflate or deflate asynchronously during breathing. ### Claim 22 (depends on 20) The method of claim 20, further comprising calculating a fissure defect score based on a size of the fissure defect; wherein determining whether collateral ventilation is present or above a threshold level is further based on the calculated defect score. ### Claim 23 (depends on 22) The method of claim 22, comprising determining a degree of collateral ventilation based on the changes in volume of the first and second lung compartments. ### Claim 24 (depends on 20) The method of claim 20, further comprising creating a report indicating lung compartments determined to have collateral ventilation or degrees of collateral ventilation for lung compartments. ### Claim 25 (depends on 24) The method of claim 24, wherein the report comprises one or more potential treatment sites and one or more suggested implantable devices for the potential treatment site to cause lung volume reduction or reduce hyperinflation; wherein the first or second lung compartment is determined not to have collateral ventilation or a degree of collateral ventilation below a threshold level and the potential treatment site is an airway leading to the first or second lung compartment. ### Claim 26 (depends on 24) The method of claim 24, wherein the report comprises one or more potential treatment sites and one or more suggested therapeutic agents or implantable devices to be delivered to the potential treatment site to cause lung volume reduction or reduce hyperinflation; wherein the first or second lung compartment is determined to have collateral ventilation or a degree of collateral ventilation above a threshold level and the potential treatment site comprises one or more regions within the first or second lung compartment. ### Claim 27 (depends on 24) The method of claim 24, wherein the report comprises one or more potential treatment sites and one or more suggested therapeutic agents or implantable devices to be delivered to the potential treatment site to minimize collateral ventilation between lung compartments; wherein the first or second lung compartment is determined to have collateral ventilation or a degree of collateral ventilation above a threshold level and the potential treatment site comprises an airway leading to the fissure defect.