Antibody-cytokine engrafted proteins and methods of use for immune related disorders
AssigneeNovartis AG
InventorsYaiza Diaz-De-Durana, Michael DiDonato, Christophe Filippi, Shelly Meeusen, Glen Spraggon
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Abstract
The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.
Claims9
1-36. (canceled)
A method of treating an immune related disorder in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an antibody cytokine engrafted protein comprising:
- (a) a heavy chain variable region (VH), comprising Complementarity Determining Regions (CDR) HCDR1, HCDR2, HCDR3;
- and
- (b) a light chain variable region (VL), comprising LCDR1, LCDR2, LCDR3;
- and
- (c) an Interleukin 2 (IL2) molecule engrafted into a CDR of the VH or the VL.
A method of expanding Treg cells in a patient in need thereof, comprising administering an antibody cytokine engrafted protein comprising:
- (a) a heavy chain variable region (VH), comprising Complementarity Determining Regions (CDR) HCDR1, HCDR2, HCDR3;
- and
- (b) a light chain variable region (VL), comprising LCDR1, LCDR2, LCDR3;
- and
- (c) an Interleukin 2 (IL2) molecule engrafted into a CDR of the VH or the VL.
-46. (canceled)
Dependencies are inferred from the claim text.