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US 2022/0033413 A1Published application
New compound derived from streptomyces and use thereof
AssigneeKorea Institute of Ocean Science & Technology
InventorsHee Jae SHIN, Byeoung Kyu CHOI, Hwa Sun LEE, Hyi Seung LEE, Yeon Ju LEE, Jong Seok LEE, Ji Hoon LEE
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Abstract
The present invention relates to new compounds derived from marine actinomycetes Streptomyces, and the new compound according to the present invention has an inhibitory effect of NO production on BV-2 microglia stimulated with LPS, and thus can be utilized for the prevention and treatment of neuroinflammatory diseases.
Claims10
A compound represented by the following Chemical Formula 1, an optical isomer, or a pharmaceutically acceptable salt thereof:
- wherein:
- X1 is H or OR;
- R is H or —Y—Z;
- Y is carbonyl, amido, amide, C1-C6 alkyl, or C1-C6 alkylene;
- Z does not exist, or is C5-C10 substituted or unsubstituted aryl, with the proviso that when Z is C5-C10 substituted aryl, the substituent is one or more selected from the group consisting of a hydroxy group, and C1-C6 alkyl and amino groups;
- and
- X2 is C3-C12 saturated or unsaturated linear or branched alkyl, or C3-C12 alkenyl.
4 more elements
10-12. (canceled)
Dependencies are inferred from the claim text.