# US 2022/0032255 A1 · Directed Orientation Chemical Kinetics > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2022/0032255 A1 - Document ID: US20220032255A1 - Status: Published application - Kind: A1 - Application number: 17/387,533 - Filed: 2021-07-28 - Published: 2022-02-03 - Earliest claimed: 2020-07-31 - Assignees: 12198703 Canada Ltd. - Applicants: 12198703 Canada Ltd. - Inventors: David Allan Prystupa; John Stephen Pacak - Web page: https://patentgrep.com/patent/US20220032255A1 ## CPC - B01J 19/0033: {Optimalisation processes, i.e. processes with adaptive control systems (adaptive control systems per se G05B13/00)} - B01J 19/10: employing sonic or ultrasonic vibrations - B01J 19/087: {employing electric or magnetic energy} - B01J 19/12: employing electromagnetic waves - B01J 2219/0809: employing two or more electrodes - B01J 2219/12: Processes employing electromagnetic waves - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS ## Abstract A method to increase a probability of interaction of one molecule with a second molecule includes applying a sequence of temporally varying perturbations by acoustic forces and/or by electromagnetic fields or any combination thereof in at least two non-aligned directions to a volume containing the molecules. The sequence of temporally varying perturbations is chosen to produce a sequence of perturbed molecular configurations for the molecule in the volume and the sequence of perturbations is selected so as to cause the increase in probability. Initially data is obtained relating to orientations of the molecules and the sequence is selected based on the data. The data can be obtained by observation or by creating a known orientation using selected fields. ## Claims ### Claim 1 A method for directing interaction between molecules comprising: collecting the molecules within an interaction volume; applying a sequence of temporally varying perturbations in at least two non-aligned directions to the interaction volume; wherein the sequence of temporally varying perturbations is chosen to produce a sequence of perturbed molecular configurations for at least one molecule in the interaction volume; and wherein the sequence of perturbations is selected so as to cause at least one selected orientation of said at least one molecule which increases a probability of interaction of said at least one molecule with a second molecule. ### Claim 2 (depends on 1) The method according to claim 1 including obtaining data relating to orientations of at least part of at least one of the molecules wherein the sequence is selected based on the data. ### Claim 3 (depends on 2) The method according to claim 2 wherein the data is obtained by creating a known orientation using selected fields. ### Claim 4 (depends on 1) The method according to claim 1 wherein at least one of the perturbations is caused by acoustic forces and/or by electromagnetic fields including electric fields and magnetic fields, or any combination thereof. ### Claim 5 (depends on 1) The method according to claim 1 wherein at least one of the perturbations is caused by a flux of solvent molecules. ### Claim 6 (depends on 1) The method according to claim 1 wherein the sequence of perturbations includes a first state applied for a first period that induces a said selected orientation for said at least one molecule in the interaction volume. ### Claim 7 (depends on 1) The method according to claim 1 wherein at least one of said perturbations is produced by electromagnetic radiation. ### Claim 8 (depends on 1) The method according to claim 1 wherein at least one acoustic disturbance is applied to the interaction volume. ### Claim 9 (depends on 1) The method according to claim 1 wherein the sequence of perturbations is selected such that in said at least one selected orientation said at least one molecule interacts with said second molecule and does not interact with a third molecule. ### Claim 10 (depends on 1) The method according to claim 1 wherein said interaction volume comprises a series of interaction volumes where a first sequence of perturbations is applied to a first interaction volume of said series causing the first molecule and the second molecule to interact forming an interaction complex and a second sequence of perturbations is applied to a second interaction volume of said series causing interaction between said interaction complex and a third molecule wherein the interaction complex is transported from the first interaction volume to the second interaction volume. ### Claim 11 (depends on 10) The method according to claim 10 wherein said series of interaction volumes are pipelined and a different sequence of perturbations is applied to each interaction volume of said series. ### Claim 12 (depends on 1) The method according to claim 1 wherein said at least one molecule is cycled periodically through a sequence of reactive configurations by a sequence of perturbations. ### Claim 13 (depends on 1) The method according to claim 1 wherein said interaction between said at least one first molecule and said second molecule operates to change an optical property and said change in optical property is detected to determine whether said interaction has occurred. ### Claim 14 (depends on 1) The method according to claim 1 wherein said at least one first molecule comprises a plurality of different molecule types and wherein each of said different molecule types is cycled through a sequence of configurations by a sequence of perturbations so as to be tested for interaction with said second molecule as a recognition complex. ### Claim 15 (depends on 14) The method according to claim 14 wherein said interaction is determined using spectroscopic measurements. ### Claim 16 (depends on 1) The method according to claim 1 wherein said second molecule for reaction with said at least one molecule is attached to a substrate and maintained oriented thereon relative to a substrate axis. ### Claim 17 (depends on 16) The method according to claim 16 wherein said substrate is fixed. ### Claim 18 (depends on 17) The method according to claim 17 wherein said substrate bounds the interaction volume. ### Claim 19 (depends on 18) The method according to claim 18 wherein said substrate comprises a magnetic object which is oriented by a sequence of one or more magnetic fields. ### Claim 20 (depends on 1) The method according to claim 1 wherein a concentration of said least one molecule in the interaction volume is determined using spectroscopic measurements. ### Claim 21 (depends on 1) The method according to claim 1 wherein the sequence of perturbations is selected by an artificial intelligence algorithm analyzing spectra relating to said at least one molecules in the interaction volume. ### Claim 22 (depends on 1) The method according to claim 1 wherein data used to select the sequence of perturbations is obtained by detecting orientations of said at least one target molecule by: applying a sequence of temporally varying fields to a sample volume caused by acoustic forces and/or by electromagnetic fields including electric fields and magnetic fields, or any combination thereof; wherein the sequence of temporally varying fields is chosen to produce a sequence of at least two different perturbed molecular configurations for said target molecule in the sample; for at least two of said perturbed molecular configurations directing a sequence of probe radiation incident on the sample molecules wherein at least one wavelength in the incident probe radiation beam interacts with at least one sample molecule; and collecting interaction radiation that has at least in part interacted with at least one molecule in said at least two perturbed configurations. ### Claim 23 (depends on 1) The method according to claim 1 wherein an electrode linked with voltage supply is shaped to act as a Fresnel lens for radiation entering or exiting the interaction volume where the Fresnel lens is used to focus incident radiation to a point within the interaction volume while generating a spatially uniform electric field within the interaction volume. ### Claim 24 (depends on 1) The method according to claim 1 wherein the probability of interaction for said at least one molecule with said second molecule is increased and the probability of interaction of a third molecule with said second molecule is decreased. ### Claim 25 A method for applying a sequence of electromagnetic temporally varying perturbations to molecules in an interaction volume; wherein an electrode linked with a voltage supply is shaped to act as a Fresnel lens for radiation entering or exiting the interaction volume where the Fresnel lens is used to focus incident radiation to a point within the interaction volume while generating a spatially uniform electric field within the interaction volume.