# US 2022/0031972 A1 · Drug dose cartridge for an inhaler device

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- Number: US 2022/0031972 A1
- Document ID: US20220031972A1
- Status: Published application
- Kind: A1
- Application number: 17/504,598
- Filed: 2021-10-19
- Published: 2022-02-03
- Earliest claimed: 2014-06-30
- Assignees: Syqe Medical Ltd.
- Applicants: Syqe Medical Ltd.
- Inventors: Perry DAVIDSON; Aaron SCHORR; Binyamin SCHWARTZ; Roee LIFSHITZ; Shay LANDA
- Web page: https://patentgrep.com/patent/US20220031972A1

## CPC

- A61M 15/0028: {using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up}
- A61K 31/465: Nicotine; Derivatives thereof
- A61K 36/3482: {Cannabis}
- A61M 11/041: {using heaters}
- A61M 11/042: {electrical}
- A61M 15/0001: {Details of inhalators; Constructional features thereof}
- A61M 15/0003: {with means for dispensing more than one drug}
- A61M 15/002: {with air flow regulating means}
- A61M 15/0045: {using multiple prepacked dosages on a same carrier, e.g. blisters}
- A61M 15/005: {the dosages being arranged on a cylindrical surface}
- A61M 15/0051: {the dosages being arranged on a tape, e.g. strips}
- A61M 15/0061: {using pre-packed dosages having an insert inside}
- A61M 15/0065: {Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52)}
- A61M 15/0066: {with means for varying the dose size}
- A61M 15/06: Inhaling appliances shaped like cigars, cigarettes or pipes
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 1/08: for nausea, cinetosis or vertigo; Antiemetics
- A61P 1/14: Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 9/12: Antihypertensives
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/06: Antiasthmatics
- A61P 13/10: of the bladder
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/04: Antipruritics
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 25/08: Antiepileptics; Anticonvulsants
- A61P 25/14: for treating abnormal movements, e.g. chorea, dyskinesia
- A61P 25/16: Anti-Parkinson drugs
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 25/20: Hypnotics; Sedatives
- A61P 25/22: Anxiolytics
- A61P 25/24: Antidepressants
- A61P 25/30: for treating abuse or dependence
- A61P 25/32: Alcohol-abuse
- A61P 27/06: Antiglaucoma agents or miotics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/14: for RNA viruses
- A61P 31/18: for HIV
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- H05B 1/025: {For medical applications}
- H05B 3/04: Waterproof or air-tight seals for heaters
- H05B 3/265: {the insulating base being an inorganic material, e.g. ceramic (H05B3/262 takes precedence)}
- A61M 11/02: operated by air {or other gas} pressure applied to the liquid {or other product} to be sprayed or atomised {(sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C)}
- A61M 15/0021: {Mouthpieces therefor}
- A61M 15/0091: {mechanically breath-triggered}
- A61M 2205/0216: Materials providing elastic properties, e.g. for facilitating deformation and avoid breaking
- A61M 2205/3303: Using a biosensor
- A61M 2205/3331: Pressure; Flow
- A61M 2205/3334: Measuring or controlling the flow rate
- A61M 2205/3368: Temperature
- A61M 2205/3569: sublocal, e.g. between console and disposable
- A61M 2205/3592: using telemetric means, e.g. radio or optical transmission
- A61M 2205/36: related to heating or cooling
- A61M 2205/502: User interfaces, e.g. screens or keyboards
- A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient
- H05B 2203/021: Heaters specially adapted for heating liquids
- H05B 2203/022: Heaters specially adapted for heating gaseous material
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- H05B: ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL

## Abstract

Devices and methods are described for preparing, managing, and/or administering metered doses of substances for vaporized administration. In some embodiments, dose cartridges comprising at least one botanical substance include a heating element integrated into the cartridge in close contact with the botanical substance. In some embodiments, cartridge-mounted doses are stored in a magazine, optionally in carousel form, before use. Transport of a cartridge from a magazine to an electrically operated vaporizing chamber which activates the heating element is provided by a mechanical pickup means.

## Claims

### Claim 1

A dose cartridge dispensing assembly comprising:
a dose cartridge dispenser which stores a plurality of dose cartridges therein; the dose cartridge dispenser comprising a housing including at least one aperture leading into and out of an inner volume defined by said housing;
at least one administration element shaped and sized to be at least partially inserted into said at least one aperture, said administration element configured to carry a dose cartridge out from said dose cartridge dispenser or back into said dose cartridge dispenser via said at least one aperture; wherein said administration element is configured to engage a first dose cartridge in a manner which geometrically blocks engagement of said administration element to another, second dose cartridge, such that removal of said second dose cartridge from said dose cartridge dispenser is enabled only when said first dose cartridge is returned by said administration element back into said dose cartridge dispenser.

### Claim 2 (depends on 1)

The assembly according to claim 1, wherein said plurality of dose cartridges are arranged on a carousel inside said housing of said dose cartridge dispenser, and wherein insertion of said administration element into said at least one aperture triggers rotation of said carousel.

### Claim 3 (depends on 1)

The assembly according to claim 1, wherein said plurality of dose cartridges are transported within said housing under motorized control.

### Claim 4 (depends on 3)

The assembly according to claim 3, wherein said dose cartridge dispenser comprises a stepper motor configured to drive movement of said plurality of dose cartridges within said housing.

### Claim 5 (depends on 1)

The assembly according to claim 1, wherein said plurality of dose cartridges are accessible in a sequential order.

### Claim 6 (depends on 1)

The assembly according to claim 1, wherein said plurality of dose cartridges are accessible in a non-sequential order.

### Claim 7 (depends on 1)

The assembly according to claim 1, wherein each of said plurality of dose cartridges comprises one or more latching elements which enable transport of said dose cartridge out from said dose cartridge dispenser or back into said dose cartridge dispenser.

### Claim 8 (depends on 1)

The assembly according to claim 1, wherein each of said plurality of dose cartridges comprises a flat pallet from which at least one active substance is vaporized.

### Claim 9 (depends on 8)

The assembly according to claim 8, wherein said at least one active substance comprises THC and/or nicotine.

### Claim 10 (depends on 8)

The assembly according to claim 8, wherein each of said plurality of dose cartridges comprises an electrically resistive heating element configured to heat said granulated material.

### Claim 11 (depends on 1)

The assembly according to claim 1, wherein said dose cartridge dispenser is a linear-type magazine in which said plurality of dose cartridges are stacked one on top of the other.

### Claim 12 (depends on 11)

The assembly according to claim 11, wherein said at least one aperture comprises a first slot through which a dose cartridge is removed from said magazine and a second slot through which a used dose cartridge is returned to said magazine.

### Claim 13 (depends on 1)

The assembly according to claim 1, comprising two administration elements configured to engage two dose cartridges concomitantly.

### Claim 14 (depends on 1)

The assembly according to claim 1, wherein said administration element comprises a dose puller/pusher which forms a part of an inhaler device configured for use with said dose cartridge dispenser, the dose puller/pusher configured to extend from said inhaler device and into said housing of said dose cartridge dispenser via said at least one aperture.

### Claim 15 (depends on 14)

The assembly according to claim 14, wherein said inhaler device comprises at least one airflow conduit and wherein said dose puller/pusher positions said dose cartridge in said inhaler device such that said dose cartridge is clamped within said airflow conduit.

### Claim 16

A method of dispensing a dose cartridge from a dose cartridge dispenser for use with an inhaler device, the dose cartridge dispenser comprising a housing in which a plurality of dose cartridges are stored, the method comprising:
returning, via an administration element, a dose cartridge that was used in the inhaler device back into said housing of said dose cartridge dispenser;
only if said used dose cartridge was returned into said housing by said administration element, removing, via said same administration element, a second, unused dose cartridge out from said housing of said dose cartridge dispenser and into said inhaler device for use.

### Claim 17 (depends on 16)

The method according to claim 16, comprising sensing if the administration element is holding said used dose cartridge.

### Claim 18 (depends on 16)

The method according to claim 16, comprising moving said plurality of dose cartridges inside said housing of said dose cartridge dispenser to place said second, unused dose cartridge in a use position from which said unused dose cartridge can be engaged by said administration element.

### Claim 19 (depends on 18)

The method according to claim 18, wherein said moving is controlled by a controller of said inhaler device according to a dosing regimen, placing selected dose cartridges in said use position.

### Claim 20 (depends on 16)

The method according to claim 16, wherein only one dose cartridge can be engaged by said administration element at a time.

### Claim 21 (depends on 16)

The method according to claim 16, wherein said dose cartridge dispenser housing is shaped and configured to allow access to only one dose cartridge at a time.

### Claim 22 (depends on 16)

The method according to claim 16, comprising, prior to said removing, selecting a dose cartridge according to an administration regimen.