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US 2022/0031908 A1Published application
Injectable Therapeutic Biocompatible Co-Polymers and Methods of Making and Using Same
OwnerJuana Mendenhallinventor
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Abstract
Biocompatible copolymers and thermo-responsive hydrogels formed from the copolymers are disclosed. The biocompatible copolymers include monomers comprising polysaccharides or derivatives thereof, therapeutic agents or derivatives thereof and thermo-responsive monomers and are cross-linked with an acrylamide-containing crosslinker. The hydrogels are used as implant materials to treat or prevent joint damage or osteoarthritis in a subject.
Claims25
A biocompatible copolymer, comprising:
- a first plurality of monomers each comprising a polysaccharide or derivative thereof;
- a second plurality of monomers each comprising a therapeutic agent or derivative thereof;
- a third plurality of monomers each comprising a thermo-responsive monomer;
- and
- an acrylamide-containing cross-linking agent.
2 more elements
(canceled)
(canceled)
(canceled)
(canceled)
A co-polymerizable composition, comprising:
- n-vinyl caprolactam;
- methacrylated hyaluronic acid;
- a therapeutic agent or derivative thereof containing a vinyl functional group;
- and
- an acrylamide containing crosslinking agent.
2 more elements
-30. (canceled)
Dependencies are inferred from the claim text.