# US 2022/0031237 A1 · Systems, methods and computer program product for monitoring vascular perfusion in replanted tissue flaps > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2022/0031237 A1 - Document ID: US20220031237A1 - Status: Published application - Kind: A1 - Application number: 17/299,628 - Filed: 2019-12-02 - Published: 2022-02-03 - Earliest claimed: 2018-12-03 - Assignees: Secretary, Department of Biotechnology - Applicants: Secretary, Department of Biotechnology - Inventors: Nirmal Kumar; Aniket Anand Kulkarni; Deepika Dixit; Yasuyuki Matsuura; Prashant Jha; Ashish Bichpuriya - Web page: https://patentgrep.com/patent/US20220031237A1 ## CPC - A61B 5/4848: {Monitoring or testing the effects of treatment, e.g. of medication} - A61B 5/02055: {Simultaneously evaluating both cardiovascular condition and temperature} - A61B 5/026: Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)} - A61B 5/14551: {for measuring blood gases} - A61B 5/7425: {Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image} - G16H 40/63: for local operation - A61B 5/01: Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20) - A61B 5/024: Measuring pulse rate or heart rate - A61B 5/1032: {Determining colour of tissue for diagnostic purposes} - A61B 5/14542: {for measuring blood gases (A61B5/14551 takes precedence)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract The invention provides systems, methods and computer program products for monitoring vascular perfusion in replanted tissue flaps. Specifically, the invention provides a non-invasive solution for monitoring of vascular perfusion at a site of tissue replantation, and that is capable of detecting problems in vascular perfusion and raising alarms in real times. The invention achieves the above function objectives by means of non-invasive sensors that continuously monitor selected parameters related to tissue condition. The monitored data parameters are used to determine a real time condition of replanted tissue. ## Claims ### Claim 1 An apparatus for non-invasive monitoring of vascular perfusion at a site of tissue replantation, comprising: a processor; a transceiver; one or more of a first temperature sensor, a first SpO2 sensor, a first pulse sensor and a first color sensor; wherein the processor is configured to: receive from one or more of a first temperature sensor, a first SpO2 sensor, a first pulse sensor and a first color sensor respectively, one or more of temperature data, SpO2 data, pulse data and color data corresponding to a tissue replantation site; and evaluate whether any of the received temperature data, SpO2 data, pulse data and color data received, that any of a detected temperature parameter value, SpO2 parameter value, pulse parameter value and color parameter value corresponding to the tissue replantation site, is consistent with one or more range of normal values for temperature data, SpO2 data, pulse data or color data. ### Claim 2 (depends on 1) The apparatus as claimed in claim 1, configured such that the one or more normal values for temperature data, SpO2 data, pulse data or color data comprise a range of predefined normal values associated with healthy tissue. ### Claim 3 (depends on 1) The apparatus as claimed in claim 1, wherein the one or more normal values for temperature data, SpO2 data, pulse data or color data comprise one or more of temperature data values received from a second temperature sensor, SpO2 data received from a second SpO2 sensor, pulse data received from a second pulse sensor and color data received from a second color sensor, wherein any of the second temperature sensor, second SpO2 sensor, second pulse sensor, and second color sensor are configured to detect data values corresponding to a healthy tissue site. ### Claim 4 (depends on 1) The apparatus as claimed in claim 1, comprising all of a first temperature sensor, a first SpO2 sensor, a first pulse sensor and a first color sensor. ### Claim 5 (depends on 16) The apparatus as claimed in claim 16, configured such that the alarm is generated based on an evaluation of two or more of temperature data, SpO2 data, pulse data and color data corresponding to the tissue replantation site. ### Claim 6 (depends on 5) The apparatus as claimed in claim 5, configured such that the alarm is generated based on an evaluation of all of temperature data, SpO2 data, pulse data and color data corresponding to the tissue replantation site. ### Claim 7 (depends on 1) The apparatus as claimed in claim 1, configured such that data received from any of the first temperature sensor, first SpO2 sensor, first pulse sensor and first color sensor respectively is magnified for display, wherein a magnified output is determined as: Magnified Output=(((Sensor Output)−(Baseline Output))×(Magnification Factor))+(Baseline Value). ### Claim 8 A method for non-invasive monitoring of vascular perfusion at a site of tissue replantation, comprising implementing at a processor, the steps of: receiving from one or more of a first temperature sensor, a first SpO2 sensor, a first pulse sensor and a first color sensor respectively, one or more of temperature data, SpO2 data, pulse data and color data corresponding to a tissue replantation site; and evaluate whether any of the received temperature data, SpO2 data, pulse data and color data received, that any of a detected temperature parameter value, SpO2 parameter value, pulse parameter value and color parameter value corresponding to the tissue replantation site, is consistent with one or more range of normal values for temperature data, SpO2 data, pulse data or color data. ### Claim 9 (depends on 8) The method as claimed in claim 8, wherein said one or more normal values comprising a range of predefined normal values associated with healthy tissue. ### Claim 10 (depends on 8) The method as claimed in claim 8, wherein the one or more normal values for temperature data, SpO2 data, pulse data or color data comprise one or more of temperature data values received from a second temperature sensor, SpO2 data received from a second SpO2 sensor, pulse data received from a second pulse sensor and color data received from a second color sensor, wherein any of the second temperature sensor, second SpO2 sensor, second pulse sensor, and second color sensor are configured to detect data values corresponding to a healthy tissue site. ### Claim 11 (depends on 8) The method as claimed in claim 8, comprising receiving all of temperature data, SpO2 data, pulse data and color data corresponding to a tissue replantation site. ### Claim 12 (depends on 18) The method as claimed in claim 18, wherein the alarm is generated based on an evaluation of two or more of temperature data, SpO2 data, pulse data and color data corresponding to the tissue replantation site. ### Claim 13 (depends on 12) The method as claimed in claim 12, wherein the alarm is generated based on an evaluation of all of temperature data, SpO2 data, pulse data and color data corresponding to the tissue replantation site. ### Claim 14 (depends on 8) The method as claimed in claim 8, wherein data received from any of the first temperature sensor, first SpO2 sensor, first pulse sensor and first color sensor respectively is magnified for display, wherein a magnified output is determined as: Magnified Output=(((Sensor Output)−(Baseline Output))×(Magnification Factor))+(Baseline Value). ### Claim 15 A computer program product for non-invasive monitoring of vascular perfusion at a site of tissue replantation, comprising a non-transitory computer readable medium having computer readable instructions for implementing the steps of: receiving from one or more of a first temperature sensor, a first SpO2 sensor, a first pulse sensor and a first color sensor respectively, one or more of temperature data, SpO2 data, pulse data and color data corresponding to a tissue replantation site; and evaluate whether any of the received temperature data, SpO2 data, pulse data and color data received, that any of a detected temperature parameter value, SpO2 parameter value, pulse parameter value and color parameter value corresponding to the tissue replantation site, is consistent with one or more range of normal values for temperature data, SpO2 data, pulse data or color data. ### Claim 16 (depends on 1) The apparatus as claimed in claim 1, wherein the processor generates an alarm in response to determining, based on any of the received temperature data, SpO2 data, pulse data and color data received, that any of a detected temperature parameter value, SpO2 parameter value, pulse parameter value and color parameter value corresponding to the tissue replantation site, is inconsistent with one or more normal values for temperature data, SpO2 data, pulse data or color data. ### Claim 17 (depends on 1) The apparatus as claimed in claim 1, wherein the processor continuously receives one or more of temperature data, SpO2 data, pulse data and color data corresponding to a tissue replantation site. ### Claim 18 (depends on 8) The method as claimed in claim 8, wherein the processor generates an alarm in response to determining, based on any of the received temperature data, SpO2 data, pulse data and color data received, that any of a detected temperature parameter value, SpO2 parameter value, pulse parameter value and color parameter value corresponding to the tissue replantation site, is inconsistent with one or more normal values for temperature data, SpO2 data, pulse data or color data. ### Claim 19 (depends on 8) The method as claimed in claim 8, wherein the processor continuously receives one or more of temperature data, SpO2 data, pulse data and color data corresponding to a tissue replantation site.