US 2022/0026431 A1 · METHODS, ARRAYS AND USES THEREOF

Abstract

The present invention provides a method for diagnosing or determining a pancreatic cancer-associated disease state comprising or consisting of the steps of: (a) providing a sample from an individual to be tested; and (b) determining a biomarker signature of the test sample by measuring the presence and/or amount in the test sample of two or more biomarkers selected from the group defined in Table A; wherein the presence and/or amount in the test sample of two or more biomarkers selected from the group defined in Table A is indicative of the pancreatic cancer-associated disease state in the individual; uses and methods of determining a pancreatic cancer-associated disease state, and methods of treating pancreatic cancer, together with arrays and kits for use in the same.

Claims20

Dependent claims

A method for diagnosing or determining a pancreatic cancer-associated disease state comprising the steps of:

(a) providing a sample from an individual to be tested;
(b) measuring the presence and/or amount in the test sample of the biomarkers:
(i) osteoprotegerin (OPG) and/or von Willebrand factor (VWF);
(ii) gelsolin (GSN) and/or 3-hydroxyacyl-CoA dehydrogenase type-2 (HADH2);
(iii) insulin-like growth factor-binding protein 3 (IGFBP3);
(iv) Complement Factor B;
(v) mucin 16 (MUC16), ficolin-2 (FCN2) and/or mannan-binding lectin serine protease 2 (MASP2);
(vi) Complement C4;
(vii) Complement C5;
(viii) Cystatin C;
and (ix) CA 19-9;
and
(c) treating the individual diagnosed with the pancreatic cancer-associated disease state with a pancreatic cancer therapy, wherein the presence and/or amount in the test sample of the biomarkers recited in step (b) is indicative of the pancreatic cancer-associated disease state in the individual.

10 more elements

Dependencies are inferred from the claim text.

Methods, arrays and uses thereof

Life of this patent

Methods, arrays and uses thereof

Life of this patent

Abstract

Claims20