Ubiquitin-specific peptidase 24 inhibitor, medicinal composition and method of delaying or reversing multidrug resistance in cancers using the same
AssigneeNational Cheng Kung University
InventorChien-Chung HUNG
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Abstract
The present invention relates to a ubiquitin-specific peptidase 24 inhibitor, a medicinal composition and a method of delaying or reversing multidrug resistance in cancers using the same. The USP24 inhibitor, which includes a shUSP24 RNA and/or a carbonyl substituted phenyl compound, can serve as a chemosensitizing agent for inhibiting the drug pump out, cancer stemness and genomic instability of cancer cells, thereby being applied to a medicinal composition and a method for delaying or reversing multidrug resistance in cancers.
Claims42
A method for specifically inhibiting ubiquitin-specific peptidase 24 (USP24) in a cancer cell, comprising:
- administering a medicinal composition to a cancer cell which is suspicious of a cancerous or undifferentiated phenotype expressing multidrug resistance, wherein the medicinal composition comprises:
- a chemotherapeutic drug;
- and
- a chemosensitizing agent comprising a ubiquitin-specific peptidase 24 (USP24) inhibitor, wherein the USP24 inhibitor comprises a short interfering nucleic acid (siNA) and/or a carbonyl substituted phenyl compound, and the siNA is a short interfering ribonucleic acid (siRNA).
A method for delaying or reversing multidrug resistance in cancers, comprising:
- administering a medicinal composition to a cancer cell which is suspicious of a cancerous or undifferentiated phenotype expressing multidrug resistance, wherein the medicinal composition comprises:
- a chemotherapeutic drug;
- and
- a chemosensitizing agent comprising a USP24 inhibitor, wherein the USP24 inhibitor comprises a siNA and/or a carbonyl substituted phenyl compound, and the siNA is a siRNA.
A medicinal composition for specifically inhibiting USP24 in cancers, comprising:
- a chemotherapeutic drug;
- and
- a chemosensitizing agent comprising a ubiquitin-specific peptidase 24 (USP24) inhibitor, wherein the USP24 inhibitor comprises a siRNA having a sequence listed as SEQ ID NO:1 and/or a carbonyl substituted phenyl compound having a structure as formula (I), so as to inhibit USP24 in a cancer cell:
- In the formula (I), X1 represents a single bond or a nitrogen atom, n represents an integrity number of 1 or 2, Y represents a monovalent group, and X2 represents a hydrogen atom or a hydroxyl group.
A medicinal composition for delaying or reversing multidrug resistance in cancers, comprising:
- a chemotherapeutic drug;
- a chemosensitizing agent comprising a USP24 inhibitor, wherein the USP24 inhibitor comprises a siRNA having a sequence listed as SEQ ID NO:1 and/or a carbonyl substituted phenyl compound having a structure as formula (I), so as to delay or reverse multidrug resistance in a cancer cell:
- In the formula (I), X1 represents a single bond or a nitrogen atom, n represents an integrity number of 1 or 2, Y represents a monovalent group, and X2 represents a hydrogen atom or a hydroxyl group;
- and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.