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US 2022/0025335 A1Published application
Muscular dystrophy chimeric cells and method for treating muscular dystrophies
AssigneeThe Board of Trustees of the University of Illinois
InventorMaria SIEMIONOW
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Abstract
A Muscular Dystrophy Chimeric Cell generated by ex vivo fusion of a myoblast with a second myoblast, mesenchymal stem cell, or stromal cell is described as is the use of the same in the treatment of a muscular dystrophy.
Claims12
An isolated Muscular Dystrophy Chimeric Cell (MDCC) population comprising cells produced by ex vivo fusion and expansion of
- (a) a first myoblast;
- and
- (b) a second myoblast, mesenchymal stem cell, or stromal cell,
- wherein at least one of the first myoblast, second myoblast, mesenchymal stem cell, or stromal cell is from a healthy donor and the other is a dystrophin deficient cell from subject suffering from a muscular dystrophy.
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