Lactide containing polyester-polyethylene glycol triblock thermoresponsive copolymers
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsAbraham J. DOMB, Noam STEINMAN
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Abstract
The inventors of the technology disclosed herein have developed triblock copolymers of lactide-containing polyesters and poly(ethylene glycol), PEG, having thermoresponsive properties.
Claims23
A triblock copolymer constructed of a lactide-containing polyester and poly(ethylene glycol), PEG, wherein in the triblock copolymer, the PEG is of a molecular weight between 1,000 and 3,000 Da.
A poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly (D,L-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymer, wherein in the PLGA-PEG-PLGA triblock copolymer, the PEG is of a molecular weight between 1,000 and 3,000 Da, the PLGA and PEG being present at a ratio of between 1 and 4, and wherein the triblock copolymer having a gelation temperature between 10 and 50° C.
A PLGA-PEG-PLGA triblock copolymer, wherein in the PLGA-PEG-PLGA triblock copolymer, the PEG is of a molecular weight between 1,000 and 3,000 Da, one or both of the PLGA segments being constructed of lactide and glycolide (LA:GA) moieties at a ratio (LA:GA) of about 6, and wherein the triblock copolymer having a gelation temperature between 10 and 50° C.
A PLGA-PEG-PLGA triblock, characterized by:
- in PLGA-PEG-PLGA triblock copolymer, the PEG is of a molecular weight between 1,000 and 3,000 Da,
- in the PLGA-PEG-PLGA triblock copolymer, the PLGA and PEG being present at a ratio of between 1 and 4, or one or both of the PLGA segments is constructed of lactide and glycolide (LA:GA) moieties at a ratio around about 6;
- and
- the triblock copolymer having a gelation temperature between 10 and 50° C.
A PLGA-PEG-PLGA triblock copolymer material, the material being any one or more of materials in Table 1.
A method of manufacturing a PLGA-PEG-PLGA triblock copolymer having a gelation temperature between 10 and 50° C., the method comprising reacting PEG of a molecular weight between 1,000 and 3,000 Da with D,L-lactic acid (LA) and a glycolide (GA) at (1) a LA:GA ratio of about 6;
- and/or (2) with a D,L-lactic acid (LA) and a glycolide (GA) amounts sufficient to achieve a PLGA/PEG ratio of between 1 and 4;
- under conditions permitting formation of the triblock copolymer.
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Dependencies are inferred from the claim text.