Anti-apoc3 antibodies and methods of use thereof
AssigneeStaten Biotechnology B.V.
InventorsPaul DASILVA-JARDINE, Hans DE HAARD, James A. LANDRO
Life of this patent
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Abstract
The instant disclosure provides antibodies that specifically bind to ApoC3 (e.g., human ApoC3) and antagonize ApoC3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
Claims19
1-64. (canceled)
A polynucleotide encoding a heavy chain variable region (VH) and/or a light chain variable region (VL) of an antibody that specifically binds to ApoC3, wherein the VH comprises the CDRH1, CDRH2 and CDRH3 amino acid sequences of a VH amino acid sequence selected from the group consisting of SEQ ID NOs:
- 137-160, and/or the VL comprises the CDRL1, CDRL2 and CDRL3 amino acid sequences of a VL amino acid sequence selected from the group consisting of SEQ ID NOs:
- 161-183 and 151.
A polynucleotide encoding a heavy chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 137-160.
A polynucleotide encoding a light chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 161-183 and 151.
A method of producing an antibody that binds to ApoC3, the antibody comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH comprises the CDRH1, CDRH2 and CDRH3 amino acid sequences of a VH amino acid sequence selected from the group consisting of SEQ ID NOs:
- 137-160, and/or the VL comprises the CDRL1, CDRL2 and CDRL3 amino acid sequences of a VL amino acid sequence selected from the group consisting of SEQ ID NOs:
- 161-183 and 151,
- wherein the method comprises culturing a host cell comprising:
- (a) a polynucleotide encoding the VH and the VL, or a heavy chain and a light chain, of the antibody;
- (b) a first polynucleotide encoding the VH or a heavy chain of the antibody and a second polynucleotide encoding the VL or a light chain of the antibody;
- (c) a vector comprising a polynucleotide encoding the VH and the VL, or a heavy chain and a light chain, of the antibody;
- or
- (d) a first vector comprising a first polynucleotide encoding the VH or a heavy chain of the antibody and a second vector comprising a second polynucleotide encoding the VL or a light chain of the antibody,
- under conditions that allow expression of the antibody.
Dependencies are inferred from the claim text.