Protein tyrosine-tyrosine analogs and methods of using the same
AssigneeEli Lilly and Company
InventorsDaniel Anthony Briere, Daniel Christopher Lopes, Avinash Muppidi
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Abstract
PYY analogs are disclosed that include modifications that increase half-life when compared to native, human PYY, as well as additional modifications that increase potency and selectivity to the NPY2 receptor. Pharmaceutical compositions also are disclosed that include one or more of the PYY analogs described herein in a pharmaceutically acceptable carrier. Methods of making and using the PYY analogs also are disclosed, especially for treating obesity and obesity-related diseases and disorders such as type II diabetes mellitus.
Claims15
1-28. (canceled)
A method of treating obesity or an obesity-related disease or disorder, the method comprising the step of:
- administering to an individual in need thereof an effective amount of a Peptide Tyrosine-Tyrosine (PYY) analog comprising a structure selected from the group consisting of:
A pharmaceutical composition comprising:
- at least one Peptide Tyrosine-Tyrosine (PYY) analog comprising a structure selected from the group consisting of:
Dependencies are inferred from the claim text.