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US 2022/0025002 A1Published application
Stapled peptide inhibitors of nemo as potential anti-inflammatory and anti-cancer drugs
AssigneeInstitut Pasteur
InventorsFabrice AGOU, Alix BOUCHARLAT, Yves-Marie COIC, Françoise BALEUX
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Abstract
The invention concerns stapled peptide inhibitors of NEMO which inhibit the Nuclear Factor κB (NF-κB) signaling pathway and are useful as medicine candidates, in particular as anti-inflammatory or anticancer drugs.
Claims15
A peptide, comprising an amino sequence (I) which is at least 60% identical to the amino acid sequence SEQ ID NO:
- 1, and further comprising at least one macrocycle-forming linker connecting a first amino acid to a second amino acid of said sequence (I).
Dependencies are inferred from the claim text.