Peptides for Covid-19 Prevention and Treatment
AssigneeSotira Covid, LLC
InventorsAvik Roy, Carl Gunnar Gottschalk
Life of this patent
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Abstract
Embodiments include therapeutic peptides for preventing or reducing the transmission of a coronavirus such as SARS-CoV2. Also included are methods of using therapeutic peptides for reducing or preventing transmission of a coronavirus such as SARS-CoV2. The therapeutic peptides can prevent a region of the surface glycoprotein “spike” on SARS-CoV2 from interacting with angiotensin converting enzyme-2 (ACE-2) of host cells.
Claims20
A method of preventing or treating a virus infection in a patient that is susceptible to the virus infection comprising steps of:
- a) administering a peptide that binds to angiotensin converting enzyme-2 (ACE-2) receptor on a host cell of the patient, and
- b) preventing or attenuating formation of a complex between a viral surface protein and a receptor on a host cell.
A method of preventing or treating a coronavirus virus infection in a patient that is susceptible to the virus infection, comprising a step of administering a therapeutic amount of the peptide of SEQ ID NO:
- 1 to the patient.
A method of preventing a virus infection in a patient that is susceptible to the virus infection comprising steps of:
- a) identifying a formation of a complex between the virus and a host cell,
- b) characterizing a chemical interaction in the complex between a surface protein on the virus and a receptor on the host cell,
- c) identifying a protein sequence on the virus involved in the chemical interaction,
- d) producing a peptide having at least 90% sequence identity to the protein sequence, and
- e) administering the peptide to a patient to prevent or attenuate formation of the complex between the virus and the host cell.
Dependencies are inferred from the claim text.